Microglia in the Regenerating and Degenerating Central Nervous System

1. Front Matter

   Pages i-xi

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2. Physiology and Pathophysiology of Microglial Cell Function

   • Wolfgang J. Streit

   Pages 1-14

3. Roles of Microglia in the Developing Avian Visual System

   • Julio Navascués, Miguel A. Cuadros, Ruth Calvente, José L. Marín-Teva

   Pages 15-35

4. Microglial Ion Channels

   • Claudia Eder

   Pages 36-57

5. Calcium Signaling in Microglial Cells

   • Thomas Möller

   Pages 58-78

6. Microglia as a Source and Target of Cytokine Activities in the Brain

   • Uwe-Karsten Hanisch

   Pages 79-124

7. Microglia and Macrophage Responses in Cerebral Ischemia

   • Guido Stoll, Sebastian Jander, Michael Schroeter

   Pages 125-151

8. Role of Microglia and Macrophages in Secondary Injury of the Traumatized Spinal Cord: Troublemakers or Scapegoats?

   • Phillip G. Popovich

   Pages 152-165

9. Microglial Response in the Axotomized Facial Motor Nucleus

   • Gennadij Raivich

   Pages 166-187

10. Neuroprotective Roles of Microglia in the Central Nervous System

    • Kazuyuki Nakajima, Shinichi Kohsaka

    Pages 188-208

11. Influences of Activated Microglia/Brain Macrophages on Spinal Cord Injury and Regeneration

    • Alexander G. Rabchevsky

    Pages 209-226

12. Opportunities for Axon Repair in the CNS: Use of Microglia and Biopolymer Compositions

    • Joshua B. Stopek, Wolfgang J. Streit, Eugene P. Goldberg

    Pages 227-244

13. Beta Amyloid Protein Clearance and Microglial Activation

    • Sally A. Frautschy, Greg M. Cole, March D. Ard

    Pages 245-274

14. Microglia and Aging in the Brain

    • Caleb E. Finch, Todd E. Morgan, Irina Rozovsky, Zhong Xie, Richard Weindruch, Tomas Prolla

    Pages 275-305

15. Back Matter

    Pages 307-315

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Over the past decade, the study of microglial cells has gained increasing importance, in particular for those working in the fields of degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, currently the most widely studied disorder of the central nervous system. In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the vitally important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and also reviews microglial cell function and physiology. Cellular neurobiologists will find that this is a valuable guide to the importance and role of microglia in the CNS.

• Activation
• Alzheimer
• Calcium
• Macrophages
• Nervous System
• cells
• influence
• pathophysiology
• physiology

• Department of Neuroscience, University of Florida College of Medicine, Gainesville, USA

  Wolfgang J. Streit

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