Infectious Disease Informatics

1. Front Matter

   Pages i-xii

   PDF

2. Informatics for Infectious Disease Research and Control

   • Vitali Sintchenko

   Pages 1-26

3. Bioinformatics of Microbial Sequences

   • Phil Giffard

   Pages 27-52

4. Mining Databases for Microbial Gene Sequences

   • Richard Christen

   Pages 53-71

5. Comparative Genomics of Pathogens

   • Elena P. Ivanova, Arkadiy Kurilenko, Feng Wang, Russell J. Crawford

   Pages 73-91

6. Systems Microbiology: Gaining Insights in Transcriptional Networks

   • Riet De Smet, Karen Lemmens, Ana Carolina Fierro, Kathleen Marchal

   Pages 93-122

7. Host–Pathogen Systems Biology

   • Christian V. Forst

   Pages 123-147

8. Text Mining for Discovery of Host–Pathogen Interactions

   • Stephen Anthony, Vitali Sintchenko, Enrico Coiera

   Pages 149-165

9. A Network Approach to Understanding Pathogen Population Structure

   • Caroline O. Buckee, Sunetra Gupta

   Pages 167-185

10. Computational Epitope Mapping

    • Matthew N. Davies, Darren R. Flower

    Pages 187-202

11. Pangenomic Reverse Vaccinology

    • Claudio Donati, Duccio Medini, Rino Rappuoli

    Pages 203-221

12. Immunoinformatics: The Next Step in Vaccine Design

    • Tobias Cohen, Lenny Moise, William Martin, Anne S. De Groot

    Pages 223-244

13. Understanding the Shared Bacterial Genome

    • Jonathan R Iredell, Sally R. Partridge

    Pages 245-261

14. Computational Grammars for Interrogation of Genomes

    • Jaron Schaeffer, Afra Held, Guy Tsafnat

    Pages 263-278

15. In silico Discovery of Chemotherapeutic Agents

    • Lyn-Marie Birkholtz, Peter Burger, Samia Aci, Hélène Valadié, Ana Lucia da Costa, Loraine Brillet et al.

    Pages 279-304

16. Informatics for Healthcare Epidemiology

    • Bala Hota

    Pages 305-321

17. Automated, High-throughput Surveillance Systems for Public Health

    • Ross Lazarus

    Pages 323-344

18. Microbial Genotyping Systems for Infection Control

    • Matthew O’Sullivan

    Pages 345-358

19. Temporal and Spatial Clustering of Bacterial Genotypes

    • Blanca Gallego

    Pages 359-371

20. Infectious Disease Ontology

    • Lindsay Grey Cowell, Barry Smith

    Pages 373-395

There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the genomics of pathogens with epidemic potential. This volume addresses the growing need for the critical overview of recent developments in microbial genomics and biomedical informatics relevant to the control of infectious diseases. This field is rapidly expanding, and attracts a wide audience of clinicians, public health professionals, biomedical researchers and computer scientists who are fascinated by the complex puzzle of infectious disease. This book takes a multidisciplinary approach with a calculated move away from the traditional health informatics topics of computerized protocols for antibiotic p- scribing and pathology testing. Instead authors invite you to explore the emerging frontiers of bioinformatics-guided pathogen profiling, the system microbiolo- enabled intelligent design of new drugs and vaccines, and new ways of real-time biosurveillance and hospital infection control. Throughout the book, references are made to different products supplied by public sources and commercial vendors, but this is not an endorsement of these products or vendors.

• Annotation
• Cancer
• Epidemiology
• Migration
• Public Health
• antigen
• antimicrobial
• bacteria
• infection
• infection control
• infectious disease
• infectious diseases
• molecular epidemiology
• prevention
• vaccine

• Sydney Medical School, University of Sydney, Sydney, Australia

  Vitali Sintchenko

Vitali Sintchenko (MBBS, PhD, FRCPA, FACHI) is a clinical microbiologist and informatician with the Sydney Medical School, The University of Sydney, Australia.

Policies and ethics