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The Rho GTPases in Cancer

  • Book
  • © 2010

Overview

Editors:
  1. Kenneth Golen

    1. Dept. Biological Sciences, University of Delaware, Newark, U.S.A.

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  • The Rho GTPases have become a very "hot topic" over the past few years

  • The interest in these molecules extends past cancer biology into normal cell biology

  • The Rho GTPases are involved in nearly all cellular process and play a role in everything from development to erectile dysfunction

  • Therefore, a book of this type would have a broader audience than just cancer biologists and clinical scientists

  • Includes supplementary material: sn.pub/extras

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xxii
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  2. An Overview of the Rho GTPases

    1. Front Matter

      Pages 1-1
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    2. Overview of Rho GTPase History

      • Ellen V. Stevens, Channing J. Der
      Pages 3-27

    3. Rho Proteins in Cancer

      • Devin T. Rosenthal, John Chadwick Brenner, Sofia D. Merajver
      Pages 29-42

  3. The Rho Regulatory Proteins in Cancer

    1. Front Matter

      Pages 44-44
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    2. RhoGDIs in Cancer

      • Anthony N. Anselmo, Gary M. Bokoch, Céline DerMardirossian
      Pages 45-58

    3. Signaling through Galpha12/13 and RGS-RhoGEFs

      • Nicole Hajicek, Barry Kreutz, Tohru Kozasa
      Pages 59-76

    4. Vav Proteins in Cancer

      • Daniel D. Billadeau
      Pages 77-92

    5. Rho GTPase-Activating Proteins in Cancer

      • Matthew W. Grogg, Yi Zheng
      Pages 93-107

  4. The Rho GTPase Proteins and Cancer

    1. Front Matter

      Pages 110-110
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    2. RhoBTB Proteins in Cancer

      • Caroline McKinnon, Harry Mellor
      Pages 111-122

    3. RhoC GTPase in Cancer Progression and Metastasis

      • Kenneth van Golen
      Pages 123-134

    4. RhoB GTPase and FTIs in Cancer

      • Minzhou Huang, Lisa D. Laury-Kleintop, George C. Prendergast
      Pages 135-153

    5. Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview

      • Heather Unger, Kenneth van Golen
      Pages 155-162

    6. The Rho-Regulated ROCK Kinases in Cancer

      • Grant R Wickman, Michael S. Samuel, Pamela A Lochhead, Michael F Olson
      Pages 163-192

  5. Back Matter

    Pages 193-206
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Keywords

About this book

Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver’s laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch’s laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasa’s labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS–RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau’s laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.

Editors and Affiliations

  • Dept. Biological Sciences, University of Delaware, Newark, U.S.A.

    Kenneth Golen

Bibliographic Information

  • Book Title: The Rho GTPases in Cancer

  • Editors: Kenneth Golen

  • DOI: https://doi.org/10.1007/978-1-4419-1111-7

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2010

  • Hardcover ISBN: 978-1-4419-1110-0Published: 17 December 2009

  • Softcover ISBN: 978-1-4899-8286-5Published: 11 September 2014

  • eBook ISBN: 978-1-4419-1111-7Published: 04 December 2009

  • Edition Number: 1

  • Number of Pages: XXII, 206

  • Topics: Cancer Research, Cell Biology, Pharmacology/Toxicology

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