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  • © 2010

Cell-Extracellular Matrix Interactions in Cancer

  • Will discuss how integrins and extracellular matrix components control cancer initiation, progression and metastasis

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
  2. The Extracellular Matrix: An Overview

    • Jeffrey H. Miner
    Pages 1-17
  3. Integrin Structure and Function

    • Manakan Betsy Srichai, Roy Zent
    Pages 19-41
  4. Cancer in Context: Importance of the Tumor Microenvironment

    • Barbara Fingleton, Conor Lynch
    Pages 43-63
  5. Basement Membrane Collagens and Cancer

    • Vadim Pedchenko, Ambra Pozzi
    Pages 65-85
  6. Laminins and Cancer Progression

    • Jerome Jourquin, Manisha Tripathi, Cherise Guess, Vito Quaranta
    Pages 87-109
  7. Fibronectins and Their Receptors in Cancer

    • Christie J. Avraamides, Judith A. Varner
    Pages 111-136
  8. Vitronectin-Binding Integrins in Cancer

    • Eric Murphy, Dwayne Stupack
    Pages 137-170
  9. Proteoglycans and Cancer

    • Ralph D. Sanderson, Yang Yang, Anurag Purushothaman, Yekaterina B. Khotskaya, Joseph P. Ritchie, Vishnu C. Ramani
    Pages 191-215
  10. Tetraspanins in Cancer

    • Andries Zijlstra
    Pages 217-243
  11. The Role of Integrin-Linked Kinase in Cancer Development and Progression

    • Paul C. McDonald, Shoukat Dedhar
    Pages 245-273
  12. Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer

    • Vita M. Golubovskaya, Elizabeth A. Beierle, Steven N. Hochwald, Elena V. Kurenova, William G. Cance
    Pages 275-305
  13. Back Matter

    Pages 307-314

About this book

Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.

Editors and Affiliations

  • Vanderbilt University Medical Center, Department of Medicine, Nashville, U.S.A.

    Roy Zent

  • Medical Center, Vanderbilt University, Nashville, U.S.A.

    Ambra Pozzi

Bibliographic Information

  • Book Title: Cell-Extracellular Matrix Interactions in Cancer

  • Editors: Roy Zent, Ambra Pozzi

  • DOI: https://doi.org/10.1007/978-1-4419-0814-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2010

  • Hardcover ISBN: 978-1-4419-0813-1Published: 14 December 2009

  • Softcover ISBN: 978-1-4899-8112-7Published: 28 November 2014

  • eBook ISBN: 978-1-4419-0814-8Published: 23 January 2010

  • Edition Number: 1

  • Number of Pages: XII, 314

  • Topics: Cancer Research, Cell Biology, Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access