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  • Reference work
  • © 2017

Cancer Therapeutic Targets

  • Offers a valuable reference work on cancer therapies for all levels of expertise

  • Structures information on cancer therapeutic targets, with regular updates

  • Provides expert editors’ overviews for each target

  • Covers relevant biology, potential as cancer targets, agents tested and available clinical data

  • Includes supplementary material: sn.pub/extras

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Table of contents (95 entries)

  1. Front Matter

    Pages i-xxxii
  2. Immunology

    1. Front Matter

      Pages 1-1
    2. AKT

      • Timothy A. Yap, Johann S. de Bono
      Pages 3-12
    3. Anti-4-1BB/4-1BBL

      • Ezra A. Bernstein, Yvonne Saenger
      Pages 13-20
    4. Anti-B7-H4

      • Jun Wang, Lieping Chen
      Pages 21-29
    5. Anti-CD40/Anti-CD40L

      • David Kotlyar, Anthony Leonardi
      Pages 31-42
    6. Anti-Idiotype Antibodies

      • John M. Timmerman
      Pages 43-55
    7. Anti-Programmed Death 1 (PD1)

      • Gordon J. Freeman, Arlene Sharpe
      Pages 57-66
    8. B7.1

      • James W. Hodge, Amanda L. Boehm, Renee N. Donahue
      Pages 67-76
    9. Bacterial Vaccines

      • Paulina Chorobik, Joanna Bereta
      Pages 77-94
    10. Brachyury

      • Claudia Palena
      Pages 95-107
    11. CCL21

      • Sherven Sharma, Minu K. Srivastava, Marni-Harris White, Dorthe Schaue, Maie St John, Gang Zhang et al.
      Pages 109-116
    12. CD4+ T Cells

      • Frederick J. Kohlhapp, Andrew Zloza
      Pages 117-129
    13. CD8 T Cells

      • David Kotlyar
      Pages 131-142
    14. CEA

      • Marion Hartley, John L. Marshall
      Pages 143-155
    15. CTLA-4

      • Tasha Hughes, Howard L. Kaufman
      Pages 157-170
    16. Dendritic Cells

      • Hannah E. Goyne, Martin Cannon
      Pages 171-181
    17. DNA Vaccines

      • Eric S. Bradley, Douglas G. McNeel
      Pages 183-198
    18. EGFR, Immunology

      • Louis M. Weiner, Christina Wu
      Pages 199-208
    19. Fc Gamma R

      • Tyler R. Simpson, James P. Allison
      Pages 209-228

About this book

In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight.

The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well.

Editors and Affiliations

  • Division of Hematology & Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, USA

    John L. Marshall

About the editor

Editorial Board:

  • John L. Marshall (Editor in Chief), Department of Hematology and Oncology, Otto J Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA
  • Howard L. Kaufman, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
  • Lee M. Ellis, Department of Surgical Oncology and Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
  • Louis M. Weiner, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington DC, USA
  • Emanuel F Petricoin, Center for Applied Proteomics and Molecular Medicine, School of Systems Biology, George Mason University, Institute of Advanced Biomedical Research, Manassas, VA, USA
  • Edward P. Gelmann, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA 

Bibliographic Information

Buy it now

Buying options

eBook USD 649.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 949.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access