Overview
Intended for those with interests ranging from the fundamental basis of aging to interventions in slowing the aging process or treating age-related diseases
The study of epigenetics as it relates to aging and age-related diseases is a relatively new field that is showing considerable promise in revolutionizing how the aging process is viewed
The purpose of this book is to provide coverage of not only established aspects of epigenetics and aging, but also new approaches and perceptions in this important area of research
Includes supplementary material: sn.pub/extras
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Table of contents (26 chapters)
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Front Matter
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Epigenetics and the Aging Process
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Front Matter
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DNA Methylation and Histone Modifications in Aging
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DNA Methylation and Histone Modifications in Aging
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Front Matter
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Other Epigenetic Processes and Aging
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Front Matter
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Impact of Epigenetics on Aging
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Front Matter
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Impact of Epigenetics on Aging
Keywords
About this book
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research.
The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins.
Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Reviews
From the reviews:
“This nearly 500-pages thick book covers almost everything around the topic of how aging and age-related diseases might be affected by epigenetic processes. … Understanding the drifting and stochastic nature of aging is crucial for making any use of the epigenetic pathways to intervention, and for developing future directions in research. I surely recommend this book, which will help to open up many doors towards achieving that.” (Suresh I. S. Rattan, Biogerontology, Vol. 12, 2011)Editors and Affiliations
Bibliographic Information
Book Title: Epigenetics of Aging
Editors: Trygve O. Tollefsbol
DOI: https://doi.org/10.1007/978-1-4419-0639-7
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag New York 2010
Hardcover ISBN: 978-1-4419-0638-0Published: 18 November 2009
Softcover ISBN: 978-1-4899-8310-7Published: 28 November 2014
eBook ISBN: 978-1-4419-0639-7Published: 11 November 2009
Edition Number: 1
Number of Pages: XIX, 469
Topics: Human Genetics, Cancer Research, Pharmacology/Toxicology