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  • © 2009

Oral Delivery of Macromolecular Drugs

Barriers, Strategies and Future Trends

  • Will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
  2. Enzymatic Barriers

    • John Woodley
    Pages 1-19
  3. Gastrointestinal Mucus Gel Barrier

    • Juan Perez-Vilar
    Pages 21-48
  4. The Absorption Barrier

    • Gerrit Borchard
    Pages 49-64
  5. Strategies to Overcome the Enzymatic Barrier

    • Martin Werle, Hirofumi Takeuchi
    Pages 65-83
  6. Polymeric Permeation Enhancers

    • Hans E. Junginger
    Pages 103-122
  7. Strategies to Overcome Efflux Pumps

    • Florian Föger
    Pages 123-136
  8. Nano- and Microparticles in Oral Delivery of Macromolecular Drugs

    • Gioconda Millotti, Andreas Bernkop-Schnürch
    Pages 153-167
  9. Liposome-Based Mucoadhesive Formulations for Oral Delivery of Macromolecules

    • Pornsak Sriamornsak, Jringjai Thongborisute, Hirofumi Takeuchi
    Pages 169-193
  10. Strategies in Oral Immunization

    • Pavla Simerska, Peter Moyle, Colleen Olive, Istvan Toth
    Pages 195-222
  11. Oral Delivery of Nucleic Acid Drugs

    • Ronny Martien
    Pages 223-236
  12. Back Matter

    Pages 237-242

About this book

Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. Oral Delivery of Macromolecular Drugs will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.

Editors and Affiliations

  • Naturwissenschaftliche Fakultät, Universität Innsbruck, Innsbruck, Austria

    Andreas Bernkop-Schnürch

About the editor

Andreas Bernkop-Schnürch is the Dean of the Faculty of Chemistry and Pharmacy and Professor of Pharmaceutical Technology at the University of Innsbruck, Austria. His main interests focus on non-invasive drug delivery systems, multifunctional polymers such as thiomers, mucoadhesion and permeation enhancement. He is author of more than 200 original research and review articles and received the Research-Award of the City of Vienna (Vienna), EURAND-Award (Boston), Best of Biotech Award (Vienna), MBPW-Award (Munich), PHÖNIX Award (Mannheim), Houska-Award (Vienna) and Austrian-Nanoaward (Vienna). In addition, Andreas Bernkop-Schnürch is founder and owner of the following companies: ThioMatrix GmbH, Dr. K. Schnürch KG and Green River Polymers GmbH.

Bibliographic Information

  • Book Title: Oral Delivery of Macromolecular Drugs

  • Book Subtitle: Barriers, Strategies and Future Trends

  • Editors: Andreas Bernkop-Schnürch

  • DOI: https://doi.org/10.1007/978-1-4419-0200-9

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2009

  • Hardcover ISBN: 978-1-4419-0199-6Published: 21 August 2009

  • Softcover ISBN: 978-1-4899-8282-7Published: 08 October 2014

  • eBook ISBN: 978-1-4419-0200-9Published: 04 August 2009

  • Edition Number: 1

  • Number of Pages: XIII, 242

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Cell Biology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access