Targeted Cancer Immune Therapy

1. Front Matter

   Pages i-xi

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2. Cytokine Immune Therapy

   1. Front Matter

      Pages 1-1

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   2. Role of IL12 Family in Regulation of Antitumor Immune Response

      • Denada Dibra, Shulin Li

      Pages 3-18

   3. IL-18 in Regulation of Antitumor Immune Response and Clinical Application

      • Chintana Chirathaworn, Yong Poovorawan

      Pages 19-41

   4. Interleukin-21 and Cancer Therapy

      • Ian D. Davis, Kresten Skak, Naomi Hunder, Mark J. Smyth, Pallavur V. Sivakumar

      Pages 43-59

   5. IL-24 in Regulation of Antitumor Immune Response and in Signaling

      • Sita Aggarwal, William Hansel, Rajasree Solipuram

      Pages 61-74

   6. IL-28 and IL-29 in Regulation of Antitumor Immune Response and Induction of Tumor Regression

      • Muneo Numasaki

      Pages 75-95

   7. Passive and Active Tumor Homing Cytokine Therapy

      • Jeffry Cutrera, Shulin Li

      Pages 97-113

3. Cell-based Immune Therapy

   1. Front Matter

      Pages 116-116

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   2. New Strategies to Improve Tumor Cell Vaccine Therapy

      • Jian Qiao, Haidong Dong

      Pages 117-131

   3. Modification of Dendritic Cells to Enhance Cancer Vaccine Potency

      • Archana Monie, Chien-Fu Hung, T.-C. Wu

      Pages 133-157

   4. Dendritic Cell Vaccines for Immunotherapy of Cancer: Challenges in Clinical Trials

      • Lazar Vujanovic, Lisa H. Butterfield

      Pages 159-172

   5. A “Toll Bridge” for Tumor-Specific T Cells

      • Eduardo Davila

      Pages 173-189

   6. Engineering Adult Stem Cells for Cancer Immunotherapy

      • Wesley Burnside, Yan Cui

      Pages 191-206

   7. Animal Models for Evaluating Immune Responses of Human Effector Cells In Vivo

      • Faisal Razzaqi, Wesley M. Burnside, Lolie Yu, Yan Cui

      Pages 207-223

4. Targeted Immune Therapy

   1. Front Matter

      Pages 226-226

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   2. CD40 Stimulation and Antitumor Effects

      • Danice E. C. Wilkins, William J. Murphy

      Pages 227-239

   3. Immunocytokines: A Novel Approach to Cancer Immune Therapy

      • Stephen D. Gillies

      Pages 241-256

   4. Immune Escape: Role of Indoleamine 2,3-Dioxygenase in Tumor Tolerance

      • Jessica B. Katz, Alexander J. Muller, Richard Metz, George C. Prendergast

      Pages 257-283

   5. Adoptive Transfer of T-Bodies: Toward an Effective Cancer Immunotherapy

      • Dinorah Friedmann-Morvinski, Zelig Eshhar

      Pages 285-299

Stimulation of the immune system’s ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the novel aspects of immune therapy were described instead of attempting to cover any historical achievement. In the first section, Cytokine Immune Therapy, the IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in regard to the an- tumor function and application in treating tumors. Most of these selected cyt- ines were discovered in last 10 years. In the second section, Cell-based Immune Therapy, the focus was engineering potent immune regulatory or effector cells such as dendritic cells, T cells, and stem cells. Cell engineering design is primarily based on the increased understanding of the interaction of tumor antigen-presenting cells, antigen- specific effector cells, and the tumor microenvironment.

• TNF
• cancer
• cancer therapy
• cell
• cell therapy
• clinical trial
• cytokine
• cytokines
• immunotherapy
• tumor
• vaccine

• Sidney Kimmel Cancer Center, San Diego, U.S.A.

  Joseph Lustgarten

• Health Sciences Center, Louisiana State University, New Orleans, U.S.A.

  Yan Cui

• School of Veterinary Medicine, Louisiana State University, Baton Rouge, U.S.A.

  Shulin Li

Policies and ethics