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Cancer Microenvironment and Therapeutic Implications

Tumor Pathophysiology Mechanisms and Therapeutic Strategies

  • Book
  • © 2009

Overview

Editors:
  1. Gianfranco Baronzio

    1. Legnano (Mi) and Radiotherapy / Hyperthermia Department, Policlinico di Monza, 20052 Monza, Italy

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  2. Gianfranco Fiorentini

    1. Oncology Department, San Giuseppe Hospital, 50053 Empoli, Italy

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  3. Christopher R. Cogle

    1. University of Florida, Gainesville, USA

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  • A bird’s-eye view of cancer biology
  • A critical appraisal of cancer’s context in addition to its substance
  • Written by a team of physician-scientists merging experiences at the lab bench with the fight in the cancer clinic

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Table of contents (12 chapters)

  1. Front Matter

    Pages I-XV
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  2. Tumor Physiopathology and Microenvironment Genesis

    1. Front Matter

      Pages 1-1
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    2. Inflammation and Carcinogenesis: A Change in the Metabolic Process

      • L. Schwartz, M. IsraĂ«l, Icard Philippe
      Pages 3-18

    3. Tumor Microenvironment: Aspects of Stromal-Parenchymal Interaction

      • Attila Zalatnai
      Pages 19-38

    4. Significance of Tumor Microenvironment on the Genesis of: Interstitial Fluid, Angiogenesis, Haemostatic/Haemorheologic Abnormalities. Pathogenesis and Therapeutic Aspects

      • Gianfranco Baronzio, Isabel Freitas, Kwan Hau
      Pages 39-61

    5. Cancer, Stem Cells and the Neoplastic Niche

      • Christopher R. Cogle
      Pages 63-78

  3. Tumor Microenvironment, Therapeutic Perspectives and Strategies for Normalization

    1. Front Matter

      Pages 79-79
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    2. Barriers to Drug Delivery in Cancer: Clinical Implications

      • Gianfranco Baronzio, Isabel Freitas, Attilio Baronzio, Miriam Baronzio, Elisabetta Crespi, Paolo Antonio Netti
      Pages 81-104

    3. Hypoxia, Hyperthermia, Chemotherapy: Interactions and Opportunities

      • Giammaria Fiorentini, Maurizio Cantore, Francesco Montagnani, Alfonso Del Freo, Stefano Guadagni, Gianfranco Baronzio
      Pages 105-116

    4. Effects of Molecularly Targeting Hypoxia in Oncology

      • Giammaria Fiorentini, Camillo Aliberti, Giorgio Benea, Francesco Montagnani, Andrea Mambrini, Pier Luigi Ballardini et al.
      Pages 117-135

    5. Significance of the Tumour Microenvironment in Radiotherapy

      • Michael R. Horsman, Dietmar W. Siemann
      Pages 137-156

    6. Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations

      • Gianfranco Baronzio, Isabel Freitas, Giammaria Fiorentini, Anna Rita Crugnola, Dieter Hager, Dino Ceppodomo et al.
      Pages 157-179

    7. Effects of Tumor Microenvironment on Hyperthermia, Photodynamic and Nanotherapy

      • Gianfranco Baronzio, Attilio Baronzio, Elisabetta Crespi, Isabel Freitas
      Pages 181-201

    8. Targeting Tumour Vascularization from Bench to Bedside: Suggestions for Combination with Hyperthermia

      • Girolamo Ranieri, Annamaria Catino, Vittorio Mattioli, Vito Fazio, Gennaro Gadaleta Caldarola, Cosmo Damiano Gadaleta
      Pages 203-219

    9. New Indications for Established Drugs Able to Modify Tumour-Host Interactions

      • Annika Bundscherer, Christian Hafner
      Pages 221-240

  4. Back Matter

    Pages 241-242
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Keywords

About this book

In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology.

This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.

The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.

Editors and Affiliations

  • Legnano (Mi) and Radiotherapy / Hyperthermia Department, Policlinico di Monza, 20052 Monza, Italy

    Gianfranco Baronzio

  • Oncology Department, San Giuseppe Hospital, 50053 Empoli, Italy

    Gianfranco Fiorentini

  • University of Florida, Gainesville, USA

    Christopher R. Cogle

Bibliographic Information

  • Book Title: Cancer Microenvironment and Therapeutic Implications

  • Book Subtitle: Tumor Pathophysiology Mechanisms and Therapeutic Strategies

  • Editors: Gianfranco Baronzio, Gianfranco Fiorentini, Christopher R. Cogle

  • DOI: https://doi.org/10.1007/978-1-4020-9576-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2009

  • Hardcover ISBN: 978-1-4020-9575-7Published: 28 April 2009

  • Softcover ISBN: 978-90-481-8160-5Published: 19 October 2010

  • eBook ISBN: 978-1-4020-9576-4Published: 10 April 2009

  • Edition Number: 1

  • Number of Pages: XVI, 242

  • Topics: Cancer Research, Oncology, Pathology

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