Editors:
The first comprehensive handbook on immunosenescence
First to treat in one volume all the aspects of immunosenescence
Bridging bench research and clinical applications
Written by internationally recognised people in the field of immunosenescence
Useful for anti-aging research and clinic
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Table of contents (77 chapters)
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Front Matter
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Methods and Models for Studying Immunosenescence
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Front Matter
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Cellular Immunosenescene - T Cells
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Front Matter
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About this book
“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”
Reviews
Editors and Affiliations
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Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
Tamas Fulop
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Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Bologna, Italy
Claudio Franceschi
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Institute for Health and Life Sciences, Bunkyo-ku, Tokyo, Japan
Katsuiku Hirokawa
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ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Tübingen, Germany
Graham Pawelec
Bibliographic Information
Book Title: Handbook on Immunosenescence
Book Subtitle: basic understanding and clinical applications
Editors: Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec
DOI: https://doi.org/10.1007/978-1-4020-9063-9
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2009
Hardcover ISBN: 978-1-4020-9062-2Published: 25 February 2009
Softcover ISBN: 978-94-017-7721-6Published: 23 August 2016
eBook ISBN: 978-1-4020-9063-9Published: 27 February 2009
Edition Number: 1
Number of Pages: XXXI, 1693
Topics: Biomedicine general, Immunology, Geriatrics/Gerontology