Handbook on Immunosenescence

1. Front Matter

   Pages i-xxxi

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2. Methods and Models for Studying Immunosenescence

   1. Front Matter

      Pages 2-2

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   2. The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies

      • Anders Wikby, Jan Strindhall, Boo Johansson

      Pages 3-28

   3. Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing

      • Enrico Lugli, Leonarda Troiano, Marcello Pinti, Milena Nasi, Erika Roat, Roberta Ferraresi et al.

      Pages 29-62

   4. Mouse Models and Genetics of Immunosenescence

      • Qing Yu, Jyoti Misra Sen, Dennis Taub

      Pages 63-85

   5. Insect Models of Immunosenescence

      • Jeff Leips

      Pages 87-105

   6. Clonal Culture Models of T-cell Senescence

      • Graham Pawelec, Jürgen Kempf, Anis Larbi

      Pages 107-115

   7. Mouse Models of Influenza

      • Ian C. Brett, Bert E. Johansson

      Pages 117-130

   8. A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effect of Calorie Restriction

      • Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu, Haruyoshi Yamaza, Takuya Chiba

      Pages 131-144

   9. Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitations

      • A. A. Romanyukha, S. G. Rudnev, T. A. Sannikova, A. I. Yashin

      Pages 145-163

3. Cellular Immunosenescene - T Cells

   1. Front Matter

      Pages 166-166

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   2. Age, T-cell Homeostasis, and T-cell Diversity in Humans

      • David L Lamar, Cornelia M. Weyand, Jörg J. Goronzy

      Pages 167-192

   3. The Role of T-regulatory Cells in Immune Senescence

      • Paul Moss

      Pages 193-202

   4. Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population

      • Masanori Utsuyama, Yuko Kikuchi, Masanobu Kitagawa, Katsuiku Hirokawa

      Pages 203-218

   5. Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance

      • Janko Nikolich-Žugich, Anna Lang

      Pages 219-233

   6. T-cell Cycle and Immunosenescence: Role of Aging in the T-cell Proliferative Behaviour and Status Quo Maintenance

      • Jacek M. Witkowski

      Pages 235-255

   7. Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderly and in the T-cell Clone Longitudinal Model

      • Simona Neri, Erminia Mariani

      Pages 257-276

   8. Activation-Induced Cell Death of T-Cells in Elderly

      • Ewa Sikora, Agnieszka Brzezińska

      Pages 277-290

   9. CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells

      • Eric T. Clambey, John W. Kappler, Philippa Marrack

      Pages 291-325

   10. Generation and Gene Expression of CD28-CD8 T-cells in Human

       • Nan-ping Weng

       Pages 327-341

“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”

• Antigen
• Immunosenescence and clinical applications
• Thymus
• aging
• cancer
• frailty
• infections
• metabolic syndrome
• senescence

From the reviews: “The Handbook on Immunosenescence, a 1,650-page 2-volume encyclopedia on aging research with 78 articles, includes 5 sections … . Its strength is the broad coverage of aging, the immune system, and diseases of the elderly. For this reason, the Handbook on Immunosenescence is a worthy addition to any medical library.” (Marc E. Weksler, Gerontology, Vol. 56 (3), March, 2010)

• Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada

  Tamas Fulop

• Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Bologna, Italy

  Claudio Franceschi

• Institute for Health and Life Sciences, Bunkyo-ku, Tokyo, Japan

  Katsuiku Hirokawa

• ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Tübingen, Germany

  Graham Pawelec

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