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Applications of Mass Spectrometry in Life Safety

  • Conference proceedings
  • © 2008

Overview

Editors:
  1. Crisan Popescu

    1. DWI e.V. and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Alina D. Zamfir

    1. University “Aurel Vlaicu”, Arad, Romania

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    You can also search for this editor in PubMed   Google Scholar

  3. Nicolae Dinca

    1. University “Aurel Vlaicu”, Arad, Romania

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    You can also search for this editor in PubMed   Google Scholar

  • Mass spectrometry use to ‘Omics’
  • Mass Ssectrometry for immunology
  • Mass Spectrometry use for controlling the environment
  • Mass spectrometry for chemical structure identification

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Table of contents (16 papers)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Proteomics and Peptidomics

    1. Blue Native PAGE and Mass Spectrometry Analysis of Ephrin Stimulation-Dependent Protein-Protein Interactions in NG108-EphB2 Cells

      • Costel C. Darie, Vivekananda Shetty, Daniel S. Spellman, Guoan Zhang, Chongfeng Xu, Helene L. Cardasis et al.
      Pages 3-22

    2. Structure, Processing, and Polymerization of Rainbow Trout Egg Vitelline Envelope Proteins

      • Costel C. Darie, Eveline S. Litscher, Paul M. Wassarman
      Pages 23-36

    3. MALDI/MS Comparison of Fe-NTA Immobilized Metal Affinity Chromatography and Commercially-Available Metal Oxide Affinity Resins for Phosphopeptide Enrichment

      • Matthew B. Gates, Kenneth B. Tomer, Leesa J. Deterding
      Pages 37-54

    4. Molecular Recognition Specificity of anti-3-nitrotyrosine Antibodies Revealed by Affinity-Mass Spectrometry and Immunoanalytical Methods

      • Brînduşa-Alina Petre, Mihaela Drăguşanu, Michael Przybylski
      Pages 55-67

  6. Small Molecules

    1. Brominated Flame Retardants: Analytical, Toxicological and Environmental Aspects

      • Adrian Covaci, Alin C. Dirtu
      Pages 153-184

    2. Stereochemistry Studies of Some 1,3-dioxane Derivatives by Differential Mass Spectrometry and Computational Chemistry

      • Florian Harja, Christine Bettendorf, Ion Grosu, Nicolae Dinca
      Pages 185-191

    3. MALDI-TOF Mass Spectrometry in Textile Industry

      • Florentina-Daniela Munteanu, Nicolae Dinca, Artur Cavaco-Paulo
      Pages 193-203

    4. MALDI MS in Analysis of Keratin Fibre Proteins

      • Andrea Körner
      Pages 205-212

    5. Electrospray Ionization Tandem Mass Spectrometric Investigation of Essential Oils from Melissa officinalis (Labiatae Family) and Pellargonium ssp. (Geraniaceae Family)

      • Claudia C. Toma, Ioan B. Pancan, Marius ChiriŢă, Florina M. Vata, Alina D. Zamfir
      Pages 213-220

    6. Chemical Structure Identification by Differential Mass Spectra

      • Nicolae Dinca
      Pages 221-233

  7. Back Matter

    Pages 235-238
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Keywords

About this book

Mass spectrometry (MS) along with its hyphenated techniques is capable of high throughput, sensitivity, accuracy and selectivity for the analysis of structure and composition of almost any product. Like in electrophoresis, MS separates mo- cules based on the mass-to-charge ratio. In case of gel electrophoresis (SDS- PAGE), a well-known and efficient bioanalytical technique, proteins bear negative charges but have the same charge density, so proteins are separated according to their size. Similarly, in case of MS analysis, proteins carry the same charge, and are separated by their molecular weight. Unlike SDS-PAGE, however, modern ultra high resolution MS discerns very small mass differences and can resolve and completely identify in a single experiment species of the same nominal mass in complex biological mixtures. Consequently, MS can be used for the structural characterization, identification and sensitive detection of mixtures of biomolecules or for assessing the quality of isolated proteins (purity, integrity, or post-translational modifications, for example), carbohydrates, nucleic acids, drugs, metabolites, pollutants etc. In the post-genome era, MS is continuously developing as one of the most re- able analytical method for elucidating the structure of molecules originating from various biological matrices. The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other.

Editors and Affiliations

  • DWI e.V. and Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Germany

    Crisan Popescu

  • University “Aurel Vlaicu”, Arad, Romania

    Alina D. Zamfir, Nicolae Dinca

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