Overview
- Presents a clear and in-depth overview of both the clinical and scientific aspects of endocrine resistance in breast cancer
- Includes emerging and novel themes in breast cancer resistance development
- Reports up-to-date scientific and translational advances in this field
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Keywords
About this book
One of the main causes of failure in the treatment of breast cancer is the intrinsic presence of, or development of, drug resistance by the cancer cells. Recent studies on the mechanisms of cancer drug resistance have yielded important information highlighting both how tumour cells may escape these therapeutic constraints and that drug resistance may further impinge on tumour cell functions that may ultimately promote an adverse cell phenotype. New targets have been identified with potential therapeutic applications in resistant breast cancer leading to the subsequent evaluation of inhibitors of these targets in preclinical studies. Importantly, there is increasing evidence from such studies demonstrating the benefit of novel combination strategies as potential avenues for future drug regimens.
Written by experts in the subject area, this book covers the molecular details and functional consequences of endocrine resistance in breast cancer with particular emphasis on the future applications of novel drug combinations that may be utilized to circumvent resistance and improve anti-tumour effects. This book represents a timely publication in the field of breast cancer research, providing current knowledge in the area of drug resistance and will be important reading material for clinicians and researchers alike.
Editors and Affiliations
Bibliographic Information
Book Title: Therapeutic Resistance to Anti-hormonal Drugs in Breast Cancer
Book Subtitle: New Molecular Aspects and their Potential as Targets
Editors: Stephen Hiscox, Julia Gee, Robert I. Nicholson
DOI: https://doi.org/10.1007/978-1-4020-8526-0
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2009
Hardcover ISBN: 978-1-4020-8525-3Published: 29 January 2009
Softcover ISBN: 978-90-481-7901-5Published: 19 October 2010
eBook ISBN: 978-1-4020-8526-0Published: 11 January 2009
Edition Number: 1
Number of Pages: XII, 204
Topics: Cancer Research, Oncology