Stem Cell Research and Therapeutics

1. Front Matter

   Pages i-xvii

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2. Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration

   • Dennis O. Clegg, David Buchholz, Sherry Hikita, Teisha Rowland, Qirui Hu, Lincoln V. Johnson

   Pages 1-24

3. Progenitor Cell Transplantation for Retinal Disease

   • Henry J. Klassen

   Pages 25-44

4. Negative Regulation of Endogenous Stem Cells in Sensory Neuroepithelia: Implications for Neurotherapeutics

   • Jason A. Hamilton, Crestina L. Beites, Kimberly K. Gokoffski, Piper L. W. Hollenbeck, Shimako Kawauchi, Rosaseyla Santos et al.

   Pages 45-68

5. Epigenetic Control of Neural Stem Cell Self-Renewal and Specification

   • GuoQiang Sun, Chunnian Zhao, Yanhong Shi

   Pages 69-82

6. Neural Stem Cells and Neurogenic Niche in the Adult Brain

   • Xuekun Li, Basam Z. Barkho, Xinyu Zhao

   Pages 83-103

7. Progressing Neural Stem Cell Lines to the Clinic

   • Kenneth Pollock, John D. Sinden

   Pages 105-122

8. Human Neural Stem Cells for Biopharmaceutical Applications

   • Lilian Hook, Norma Fulton, Gregor Russell, Timothy Allsopp

   Pages 123-140

9. The Analysis of MicroRNAs in Stem Cells

   • Loyal A. Goff, Uma Lakshmipathy, Ronald P. Hart

   Pages 141-167

10. Optimized Growth of Human Embryonic Stem Cells

    • Matthew A. Singer, Jacqui Johnson, Paul Bello, Robert Kovelman, Michelle Greene

    Pages 169-180

11. Potential of Stem Cells in Liver Regeneration

    • Madhava Pai, Nataša Levičar, Nagy Habib

    Pages 181-192

12. Cell Transplantation Therapy for Myocardial Repair: Current Status and Future Challenges

    • Wangde Dai, Robert A. Kloner

    Pages 193-212

13. Surgical Stem Cell Therapy for the Treatment of Heart Failure

    • Federico Benetti, Luis Geffner, Daniel Brusich, Agustin Fronzutti, Roberto Paganini, Juan Paganini et al.

    Pages 213-225

14. Use of Combinatorial Screening to Discover Protocols That Effectively Direct the Differentiation of Stem Cells

    • Yen Choo

    Pages 227-250

15. Adult Stem Cell Therapies for Tissue Regeneration: Ex Vivo Expansion in an Automated System

    • Kristin L. Goltry, Douglas M. Smith, James E. Dennis, Jon A. Rowley, Ronnda L. Bartel

    Pages 251-274

16. The Hair Follicle Stem Cell as the Paradigm Multipotent Adult Stem Cell

    • Robert M. Hoffman

    Pages 275-287

17. Back Matter

    Pages 289-326

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This book is an updated reference for one of the most exciting field of biomedical researches- Stem Cell Research and its therapeutic applications. Stem cell research holds great promise for the treatment of many human diseases that currently lack effective therapies. The set of chapters in this book provide insights into both basic stem cell biology and clinical applications of stem cell-based cell replacement therapies for a variety of human diseases, including cardiovascular diseases, neurological disorders, and li ver degeneration. It also covers novel technologies for the culture and differentiation of both human embryonic stem cells and adult tissue stem cells. This book summarizes our current state of knowledge in stem cell research and integrates basic stem cell biology with regenerative medicine in an overall context. It is an essential reference for students, postdoctoral fellows, academic and industrial scientists, and clinicians. v Acknowledgements The editors would like to thank Ms. Jill Brantley, Rose Chavarin, Alina Haas, and Emily Sun for their administrative assistance and proof-reading of this book. We would also like to thank all the authors for their contributions. vii The editors wish to dedicate this book to our mentors Ron Evans, Fred Gage, and, in memory of Daniel E. Koshland, Jr. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Dennis O. Clegg, David Buchholz, Sherry Hikita, Teisha Rowland, Qirui Hu, and Lincoln V.

• RNA
• biology
• cell
• cell biology
• cell therapy
• liver
• population
• regenerative medicine
• screening
• stem cell
• tissue
• transplantation

• Beckman Research Intitute of City of Hope, Duarte, USA

  Yanhong Shi

• University of California, Santa Barbara, USA

  Dennis O. Clegg

Policies and ethics