Overview
- Editors:
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Janos Szebeni
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Walter Reed Army Institute of Research, Silver Spring
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Table of contents (25 chapters)
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A Piece of Complement History
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Pathways, Genetics and Gene Regulation of Complement
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- Péter Gál, Géza Ambrus, Zsolt Lőrincz, Péter Závodszky
Pages 19-43
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- György Ábel, Vincent Agnello
Pages 45-59
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- Mate Tolnay, George C. Tsokos
Pages 61-73
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Novel Regulatory Roles of Complement in Health and Disease
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- Anna Erdei, Eszter Molnár, Eszter Csomor, Zsuzsa Bajtay, József Prechl
Pages 77-96
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- Francesco Tedesco, Roberta Bulla, Fabio Fischetti
Pages 97-127
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- Claire L. Harris, B. Paul Morgan
Pages 129-166
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- Lisa Kuttner-Kondo, Edward M. Medof
Pages 167-185
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- Guillermina Girardi, Jane E. Salmon
Pages 187-199
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- György Ábel, Vincent Agnello
Pages 201-228
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Exploitation of Complement Proteins in Infection and Cancer
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- Reinhard Würzner, Peter F. Zipfel
Pages 231-248
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- Zoltán Prohászka, Ferenc D. Tóth, Dénes Bánhegyi, George Füst
Pages 249-264
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- Michael Kirschfink, Zvi Fishelson
Pages 265-304
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Role of Complement in Autoimmune Diseases, Allergy and Transplantation
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- George C. Tsokos, Mate Tolnay
Pages 307-314
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- Heiko Hawlisch, Marsha Wills-Karp, Christopher L. Karp, Jörg Köhl
Pages 315-344
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- Lilian Varga, Henriette Farkas, George Fust
Pages 345-360
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- Michael Kirschfink, Tom Eirik Mollnes
Pages 397-418
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Role of Complement in Acute Catastrophic Illnesses
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- Mary C. Walsh, Melanie L. Hart, Todd Bourcier, Deepak Bhole, Minoru Takahashi, Gregory L. Stahl
Pages 421-435
About this book
As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: “Complement, does that really exist?” I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved.
Editors and Affiliations
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Walter Reed Army Institute of Research, Silver Spring
Janos Szebeni
