Skip to main content
SpringerLink
Log in
Book cover

The Aetiology of Deep Venous Thrombosis

A Critical, Historical and Epistemological Survey

  • Book
  • © 2008

Overview

Authors:
  1. P. Colm Malone

    1. University of Birmingham, UK

    View author publications

    You can also search for this author in PubMed   Google Scholar

  2. Paul S. Agutter

    1. Theoretical and Cell Biology Consultancy, Glossop, UK

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Challenges the current consensus in the field, which accounts for in vitro clotting and bleeding diatheses but fails to explain the aetiology of DVT
  • Proposes an aetiological hypothesis to unify perspectives and stimulate new approaches to productive research
  • Revives consideration of old (and new) approaches to the prophylaxis of venous thrombosis and thromboembolism
  • The argument ranges over the origins of the central schism in biomedical research, and the need to repair it; using DVT as an example, it debates how that objective might be approached

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (13 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. Introduction to the Study of Deep Venous Thrombosis

    Pages 1-9

  3. The Coagulation Cascade and the Consensus Model of DVT

    Pages 11-29

  4. Hypercoagulability

    Pages 31-40

  5. Historical Roots

    Pages 41-55

  6. Coagulation and its Disorders: A History of Haematological Research

    Pages 57-70

  7. Virchow and the Pathophysiological Tradition in the 19th Century

    Pages 71-85

  8. The Pathophysiological Tradition after Virchow

    Pages 87-101

  9. Interrupted Circulation: The ‘Stasis’ Hypothesis and the Significance of Venous Valves

    Pages 103-119

  10. Underperfusion of Valve Pockets and the Initiation of DVT

    Pages 121-146

  11. The Role of Endothelial Hypoxia in DVT

    Pages 147-168

  12. The Valve Cusp Hypoxia Hypothesis

    Pages 169-194

  13. Molecular Changes in the Hypoxic Endothelium

    Pages 195-220

  14. Cadaver Clots or Agonal Thrombi?

    Pages 221-232

  15. Back Matter

    Pages 233-318
    Download chapter PDF
Back to top

Keywords

About this book

What we now call ‘deep venous thrombosis’ (DVT) has been studied in diverse ways during the last 200–300 years. Each of these approaches contributes to a full modern understanding of aetiology. Therefore, much of this book is a historical survey of the field. However, our remit is broader than the title might suggest: the evolution of ideas about DVT is typical in many ways of medical biology as a whole. Thus, although the aetiology of DVT may seem a narrow topic for a monograph – it implicitly excludes arterial thrombosis and marginalises prophylaxis, therapy, and even such clinically significant sequelae as pulmonary embolism – we hope to engage the reader in a much more general inquiry. Our historical investigation reveals a 160-year-old schism between two contrasting philosophies of medical and biological research, a schism that is particularly – but by no means uniquely – relevant to the study of DVT. In principle, these philosophies should be complementary rather than competing. So while we wish to elucidate the aetiology of DVT per se, we are also concerned with a more abstract and wide-ranging issue: the future accommodation or rapprochement between two conceptual and methodological traditions.

Authors and Affiliations

  • University of Birmingham, UK

    P. Colm Malone

  • Theoretical and Cell Biology Consultancy, Glossop, UK

    Paul S. Agutter

Bibliographic Information

  • Book Title: The Aetiology of Deep Venous Thrombosis

  • Book Subtitle: A Critical, Historical and Epistemological Survey

  • Authors: P. Colm Malone, Paul S. Agutter

  • DOI: https://doi.org/10.1007/978-1-4020-6650-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2008

  • Hardcover ISBN: 978-1-4020-6649-8Published: 24 January 2008

  • Softcover ISBN: 978-90-481-7689-2Published: 19 October 2010

  • eBook ISBN: 978-1-4020-6650-4Published: 31 December 2007

  • Edition Number: 1

  • Number of Pages: XXI, 318

  • Topics: Hematology, Pathology, History of Medicine, Vascular Surgery, Philosophy of Medicine

Publish with us

Policies and ethics

Back to top

Search

Navigation