Peroxiredoxin Systems

1. Front Matter

   Pages I-XIV

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2. Introduction

   • Leopold Flohé, J. Robin Harris

   Pages 1-25

3. Evolution of the Peroxiredoxins

   • Bernard Knoops, ElÉonore Loumaye, ValÉrie Van Der Eecken

   Pages 27-40

4. Structural Survey of the Peroxiredoxins

   • P. Andrew Karplus, Andrea Hall

   Pages 41-60

5. The Catalytic Mechanism of Peroxiredoxins

   • Leslie B. Poole

   Pages 61-81

6. Kinetics of Peroxiredoxins and their Role in the Decomposition of Peroxynitrite

   • Madia Trujillo, Gerardo Ferrer-Sueta, Leonor Thomson, Leopold Flohé, Rafael Radi

   Pages 83-113

7. The Peroxiredoxin Repair Proteins

   • Thomas J. Jönsson, W. Todd Lowther

   Pages 115-141

8. Peroxiredoxins in Bacterial Antioxidant Defense

   • James M. Dubbs, Skorn Mongkolsuk

   Pages 143-193

9. The NADH Oxidase-Prx System in Amphibacillus Xylanus

   • Youichi Niimura

   Pages 195-205

10. Peroxiredoxin Systems in Mycobacteria

    • Timo Jaeger

    Pages 207-217

11. Peroxiredoxin Systems of Protozoal Parasites

    • Marcel Deponte, Stefan Rahlfs, Katja Becker

    Pages 219-229

12. The Trypanothione System

    • Luise R. Krauth-Siegel, Marcelo A. Comini, Tanja Schlecker

    Pages 231-251

13. Functions of Typical 2-Cys Peroxiredoxins in Yeast

    • Brian A. Morgan, Elizabeth A. Veal

    Pages 253-265

14. The Dual Function of Plant Peroxiredoxins in Antioxidant Defence and Redox Signaling

    • Karl-Josef Dietz

    Pages 267-294

15. Mitochondrial Peroxiredoxins

    • Zhenbo Cao, J. Gordon Lindsay, Neil W. Isaacs

    Pages 295-315

16. Peroxiredoxins in the Lung with Emphasis on Peroxiredoxin VI

    • Bruno Schremmer, Yefim Manevich, Sheldon I. Feinstein, Aron B. Fisher

    Pages 317-344

17. Peroxiredoxins in Gametogenesis and Embryo Development

    • Isabelle Donnay, Bernard Knoops

    Pages 345-355

18. Peroxiredoxins in the Central Nervous System

    • Fumiyuki Hattori, Shinzo Oikawa

    Pages 357-374

19. Stress-Induced Peroxiredoxins

    • Tetsuro Ishii, Toru Yanagawa

    Pages 375-384

20. Back Matter

    Pages 385-389

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A volume within the Subcellular Biochemistry series is an appropriate setting for the first multi-author book devoted to the new family of antioxidant and cell signalling proteins, the peroxiredoxins. Within the antioxidant and cell signalling fields, even the existence of the peroxiredoxins has yet to be appreciated by many; with this book we aim to rectify this situation. We have tried to select diverse chapter topics to cover relevant aspects of the subject and to persuade knowledgeable authors to contribute a manuscript. As almost inevitable, a few authors let us down by failing to respond, others could not submit a manuscript in time for personal reasons. These unfortunately were two of the pioneers, Earl Stadtman and Sue Goo Rhee, but we appreciate that they communicated a lot of details that helped us to reconstruct the early phase of peroxiredoxin enzymology. We have thus compiled a book that competently covers the peroxiredoxin field from its beginnings through to currently relevant topics. In the introductory Chapter 1 we provide a short historical survey of the subject, based upon the early structural and enzymic studies on peroxiredoxins, and then lead into some of our current personal interests, such as the likely continuing contribution of transmission electron microscopy (TEM) for the study of high molecular mass peroxiredoxin complexes and the association of peroxiredoxins with other proteins, and the targeting of drugs against microbial peroxiredoxins, as future therapeutic approaches.

• Antioxidant
• Cell Signalling
• Oxidant Stress
• Peroxiredoxin
• Protozoa
• Thioredozin Peroxidase
• cellular processes
• hydrogen peroxide
• micro-organism
• mycobacteria
• parasites
• protein
• protein family
• proteins
• regulation

• MOLISA GmbH Magdeburg, Magdeburg, Germany

  Leopold Flohé

• University of Mainz, Mainz, Germany

  J. Robin Harris

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