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Yeast as a Tool in Cancer Research

  • Book
  • © 2007

Overview

Editors:
  1. John L. Nitiss

    1. St. Jude Children's Research Hospital, Memphis, USA

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  2. Joseph Heitman

    1. Duke University Medical Center, Durham, USA

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  • Uniqueness of the topic

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xvi
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  2. From DNA Replication to Genome Instability in Schizosaccharomyces Pombe: Pathways to Cancer

    • Julie M. Bailis, Susan L. Forsburg
    Pages 1-35

  3. Dissecting Layers of Mitotic Regulation Essential for Maintaining Genomic Stability

    • Jennifer S. Searle, Yolanda Sanchez
    Pages 37-73

  4. Yeast as a Tool in Cancer Research: Nuclear Trafficking

    • Anita H. Corbett, Adam C. Berger
    Pages 75-100

  5. Studies of Protein Farnesylation in Yeast

    • Nitika Thapar, Fuyuhiko Tamanoi
    Pages 101-122

  6. From Bread to Bedside: What Budding Yeast has Taught us about the Immortalization of Cancer Cells

    • Soma S. R. Banik, Christopher M. Counter
    Pages 123-139

  7. HSP90 Co-Chaperones in Saccharomyces Cerevisiae

    • Marija Tesic, Richard F. Gaber
    Pages 141-177

  8. Yeast as a Model System for Studying Cell Cycle Checkpoints

    • Carmela Palermo, Nancy C. Walworth
    Pages 179-189

  9. Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research

    • L. Ashely Cowart, Yusuf A. Hannun, Lina M. Obeid
    Pages 191-210

  10. Exploring and Restoring the p53 Pathway Using the p53 Dissociator Assay in Yeast

    • Rainer K. Brachmann
    Pages 211-232

  11. Functional Analysis of the Human p53 Tumor Suppressor and its Mutants Using Yeast

    • Alberto Inga, Francesca Storici, Michael A. Resnick
    Pages 233-288

  12. ABC Transporters in Yeast – Drug Resistance and Stress Response in a Nutshell

    • Karl Kuchler, Christoph Schüller
    Pages 289-314

  13. The FHCRC/NCI Yeast Anticancer Drug Screen

    • Susan L. Holbeck, Julian Simon
    Pages 315-346

  14. Yeast as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin

    • John R. Rohde, Sara A. Zurita-Martinez, Maria E. Cardenas
    Pages 347-374

  15. Use of Yeast as a Model System for Identifying and Studying Anticancer Drugs

    • Jun O. Liu, Julian A. Simon
    Pages 375-391

  16. Genetic Analysis of Cisplatin Resistance in Yeast and Mammals

    • Seiko Ishida, Ira Herskowitz
    Pages 393-408

  17. Using Yeast Tools to Dissect the Action of Anticancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting DNA Topoisomerases

    • Anna T. Rogojina, Zhengsheng Li, Karin C. Nitiss, John L. Nitiss
    Pages 409-427

  18. Back Matter

    Pages 429-433
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Keywords

About this book

Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein–protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind’s most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions.

Editors and Affiliations

  • St. Jude Children's Research Hospital, Memphis, USA

    John L. Nitiss

  • Duke University Medical Center, Durham, USA

    Joseph Heitman

Bibliographic Information

  • Book Title: Yeast as a Tool in Cancer Research

  • Editors: John L. Nitiss, Joseph Heitman

  • DOI: https://doi.org/10.1007/978-1-4020-5963-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2007

  • Hardcover ISBN: 978-1-4020-5962-9Published: 14 May 2007

  • Softcover ISBN: 978-94-017-8505-1Published: 18 September 2014

  • eBook ISBN: 978-1-4020-5963-6Published: 16 May 2007

  • Edition Number: 1

  • Number of Pages: XVI, 433

  • Topics: Cancer Research, Pharmacology/Toxicology, Biotechnology

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