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Inflammation in the Pathogenesis of Chronic Diseases

The COX-2 Controversy

  • Book
  • © 2007

Overview

Editors:
  1. Randall E. Harris

    1. Center of Molecular Epidemiology and Environmental Health, College of Medicine and School of Public Health, The Ohio State University Medical Center, Columbus, USA

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  2. R. Bittman

    1. Queens College, City University of New York, New York, USA

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  3. D. Dasgupta

    1. Saha Institute of Nuclear Physics, Calcutta, India

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  4. H. Engelhardt

    1. Max-Planck-Institute for Biochemistry, Munich, Germany

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  5. L. Flohe

    1. MOLISA GmbH, Magdeburg, Germany

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  6. H. Herrmann

    1. German Cancer Research Center, Heidelberg, Germany

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  7. A. Holzenburg

    1. Texas A&M University, USA

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  8. H-P. Nasheuer

    1. National University of Ireland, Galway, Ireland

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  9. S. Rottem

    1. The Hebrew University, Israel

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  10. M. Wyss

    1. DSM Nutritional Products Ltd., Basel, Switzerland

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  11. P. Zwickl

    1. Max-Planck-Institute for Biochemistry, Munich, Germany

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  • A comprehensive treatise of COX-2, inflammation and disease
  • A spell-binding look at the COX-2 controversy
  • New and exciting findings on COX-2 blockade in cancer prevention and therapy as well as the prevention of Alzheimer’s disease and other neurodegenerative conditions
  • COX-2 and the inflammogenesis of cancer

Part of the book series: Subcellular Biochemistry (SCBI, volume 42)

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Historical Perspectives

    1. Front Matter

      Pages 1-1
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    2. Anti-Inflammatory Drugs in the 21st Century

      • K.D. Rainsford
      Pages 3-27

  3. Inflammatory Mechanisms of Pathogenesis

    1. Front Matter

      Pages 29-29
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    2. Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus

      • Brice J. Weinberg, Beverley Fermor, Farshid Guilak
      Pages 31-62

    3. Obesity, Inflammation, and Vascular Disease

      • Paolo Calabro, Edward T. H. Yeh
      Pages 63-91

    4. Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer

      • Randall E. Harris
      Pages 93-126

    5. Role of COX-2 in Inflammatory and Degenerative Brain Diseases

      • Luisa Minghetti
      Pages 127-141

  4. Inflammation and Cardiovascular Disease: The Coxib Controversy

    1. Front Matter

      Pages 143-143
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    2. Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors

      • William B. White
      Pages 145-158

    3. COX-2 Inhibitors And Cardiovascular Risk

      • Daniel J. Salzberg, Matthew R. Weir
      Pages 159-174

    4. A Biological Rationale for the Cardiotoxic Effects of Rofecoxib

      • R. Preston Mason, Mary F. Walter, Charles A. Day, Robert F. Jacob
      Pages 175-190

  5. Cox-2 Blockade in Cancer Prevention and Therapy

    1. Front Matter

      Pages 191-191
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    2. Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade

      • Randall E. Harris, Joanne Beebe-Donk, Galal A. Alshafie
      Pages 193-212

    3. Strategies for Colon Cancer Prevention

      • Bandaru S. Reddy
      Pages 213-225

  6. Inflammation and Neurodegenerative Disease

    1. Front Matter

      Pages 227-227
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    2. NSAIDs for the Chemoprevention of Alzheimer’s Disease

      • Christine A. Szekely, Terrence Town, Peter P. Zandi
      Pages 229-248

    3. Inflammation in parkinson’s disease

      • Andreas Hald, Johan van Beek, Julie Lotharius
      Pages 249-279

  7. Nutrition, Inflammation and Chronic Disease

    1. Front Matter

      Pages 281-281
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    2. Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases

      • Michel E. DE Lorgeril
      Pages 283-297
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Keywords

Reviews

From the reviews: “This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. … Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. … It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.” (Vladimir N. Despotovic, Doody’s Review Service, February, 2010)

Editors and Affiliations

  • Center of Molecular Epidemiology and Environmental Health, College of Medicine and School of Public Health, The Ohio State University Medical Center, Columbus, USA

    Randall E. Harris

  • Queens College, City University of New York, New York, USA

    R. Bittman

  • Saha Institute of Nuclear Physics, Calcutta, India

    D. Dasgupta

  • Max-Planck-Institute for Biochemistry, Munich, Germany

    H. Engelhardt, P. Zwickl

  • MOLISA GmbH, Magdeburg, Germany

    L. Flohe

  • German Cancer Research Center, Heidelberg, Germany

    H. Herrmann

  • Texas A&M University, USA

    A. Holzenburg

  • National University of Ireland, Galway, Ireland

    H-P. Nasheuer

  • The Hebrew University, Israel

    S. Rottem

  • DSM Nutritional Products Ltd., Basel, Switzerland

    M. Wyss

Bibliographic Information

  • Book Title: Inflammation in the Pathogenesis of Chronic Diseases

  • Book Subtitle: The COX-2 Controversy

  • Editors: Randall E. Harris, R. Bittman, D. Dasgupta, H. Engelhardt, L. Flohe, H. Herrmann, A. Holzenburg, H-P. Nasheuer, S. Rottem, M. Wyss, … P. Zwickl

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/1-4020-5688-5

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2007

  • Hardcover ISBN: 978-1-4020-5687-1Published: 17 April 2007

  • Softcover ISBN: 978-90-481-7429-4Published: 22 November 2010

  • eBook ISBN: 978-1-4020-5688-8Published: 09 May 2007

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: XIV, 324

  • Topics: Pharmacology/Toxicology, Cancer Research, Pathology, Cardiology, Neurology, Immunology

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