Proteases in Gastrointestinal Tissues

1. Front Matter

   Pages i-xvii

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2. Protease-Activated Receptors in Gastrointestinal Function and Disease

   • Nigel W. Bunnett, Graeme S. Cottrell

   Pages 1-31

3. Matrix Metalloproteinases in Gastric Cancer

   • Nikhil I. Khushalani, Nithya Ramnath

   Pages 33-60

4. Proteases in Helicobacter pylori-Mediated Diseases

   • Thomas Wex, Michael Zack, Peter Malfertheiner

   Pages 61-87

5. Proteases in Pancreatic Disease

   • Avinash Sewpaul, Jeremy J. French, Richard M. Charnley

   Pages 89-121

6. PAR in the Pathogenesis of Pain in Pancreatic Disease

   • Pankaj J. Pasricha

   Pages 123-130

7. Importance of the Local Renin-Angiotensin System in Pancreatic Disease

   • Po Sing Leung

   Pages 131-152

8. Hepatitis C Viral Proteases And Inhibitors

   • Mingjun Huang, Avinash Phadke, Atul Agarwal

   Pages 153-181

9. Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis

   • Yao Hong Wei

   Pages 183-207

10. Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation

    • Hein W. Verspaget, Johan P. Kuyvenhoven, Cornelis F. M. Sier, Bart van Hoek

    Pages 209-234

11. MMPs and ADAMs in Inflammatory Bowel Disease

    • Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Anna Parfieniuk, Anna Moniuszko

    Pages 235-254

12. Chemokines and Matrix Metalloproteinases in Colorectal Cancer

    • Gayle G. Vaday, Stanley Zucker

    Pages 255-300

13. Angiotensin-Converting Enzyme (ACE) in Gut Inflammation

    • Fernando Magro

    Pages 301-314

14. Intestinal Apical Protein Transport in Health and Disease

    • Stephan von Hörsten, Michael Krahn, Nadine Frerker, Anja Gemeinhardt, Dennis Schwab, Silvia Slesiona et al.

    Pages 315-338

15. Back Matter

    Pages 339-343

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This, the fifth volume in the Proteases in Biology and Disease series, is devoted to Proteases in Gastrointestinal Tissues. Of course, proteases play an important role in the digestion and utilization of ingested proteins, but besides that they elicit a wide range of physiological and pathological effects. Proteases have been recognized as essential regulators, acting both locally and systemically, of normal development, growth and functioning. Dysregulation of protease expression and/or enzymatic activity is often associated with the onset or progression of disease and, thus, proteases represent interesting targets for the pharmacological therapy of e. g. cancer, chronic inflammation, graft rejection, fibrosis, diabetes, vascular disease, and viral or bacterial infections. In addition, changes in the localization, abundance or activity of proteases may serve as informative diagnostic or prognostic markers. This volume focuses on stomach, gut, pancreas, and liver and highlights the role of proteases in normal physiology and disease processes involving these tissues. The first chapter by Nigel W. Bunnett and Graeme S. Cottrell reviews the current knowledge about the protease-activated receptors (PARs) in gastrointestinal tissues. Starting with the mechanisms of activation, signal transduction, and regulation of PAR, their role in controlling gastrointestinal functions and the possible involvement in gastrointestinal diseases are summarized. In Chapter 2, Nikhil I. Khushalani and Nithya Ramnath review the role of matrix metalloproteases (MMPs) and their natural inhibitors, TIMPs, in different types of gastric cancer.

• Cancer
• Chemokine
• Fibrosis
• Inflammation
• Liver Transplantation
• Protease
• Transplantation
• pathophysiology
• physiology
• hepatology

• Otto-von-Guericke University, Magdeburg, Germany

  Uwe Lendeckel

• University of Leeds, United Kingdom

  Nigel M. Hooper

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