Solid State NMR Spectroscopy for Biopolymers

1. Front Matter

   Pages i-xiii

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2. Introduction

   Pages 1-6

3. Solid State NMR Approach

   Pages 7-29

4. Brief Outline of NMR Parameters

   Pages 31-58

5. Multinuclear Approaches

   Pages 59-88

6. Experimental Strategies

   Pages 89-126

7. NMR Constraints for Determination of Secondary Structure

   Pages 127-199

8. Dynamics

   Pages 201-217

9. Hydrogen-Bonded Systems

   Pages 219-240

10. Fibrous Proteins

    Pages 241-287

11. Polysaccharides

    Pages 289-311

12. Polypeptides as New Materials

    Pages 313-335

13. Globular Proteins

    Pages 337-345

14. Membrane Proteins I: Dynamic Picture

    Pages 347-371

15. Membrane Proteins II: 3D Structure

    Pages 373-403

16. Biologically Active Membrane-Associated Peptides

    Pages 405-429

17. Amyloid and Related Biomolecules

    Pages 431-441

18. Back Matter

    Pages 443-464

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‘‘Biopolymers’’ are polymeric materials of biological origin, including globular, membrane, and fibrous proteins, polypeptides, nucleic acids, po- saccharides, lipids, etc. and their assembly, although preference to respe- ive subjects may be different among readers who are more interested in their biological significance or industrial and/or medical applications. Nevert- less, characterizing or revealing their secondary structure and dynamics may be an equally very important and useful issue for both kinds of readers. Special interest in revealing the 3D structure of globular proteins, nucleic acids, and peptides was aroused in relation to the currently active Structural Biology. X-ray crystallography and multidimensional solution NMR sp- troscopy have proved to be the standard and indispensable means for this purpose. There remain, however, several limitations to this end, if one intends to expand its scope further. This is because these approaches are not always straightforward to characterize fibrous or membrane proteins owing to extreme difficulty in crystallization in the former, and insufficient spectral resolution due to sparing solubility or increased effective molecular mass in the presence of surrounding lipid bilayers in the latter.

• 3D structure
• Biopolymer
• Dynamics
• Membrane proteins
• Membrane-associated peptides
• Solid State NMR
• crystal
• liquid
• nuclear magnetic resonance (NMR)
• polymer
• spectroscopy

From the reviews:

"This book surveys much of the current research in the area of biological solid-state NMR spectroscopy, and as such should be of great interest to the chemical, biochemical, and biophysical communities. The level is appropriate for graduate students, and the book would be an excellent textbook for a graduate level course in biological solid-state NMR spectroscopy. Its publication is timely considering the recent numerous developments in this area … ." (Michele Auger, Journal of the American Chemical Society, Vol. 129 (10), 2007)

• Himeji Institute of Technology, Japan

  Hazime Saitô

• Hiroshima University, Japan

  Hazime Saitô

• Tokyo Institute of Technology, Japan

  Isao Ando

• Yokohama National University, Japan

  Akira Naito

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