Overview
- Includes an extensive tabulation of drug-drug interactions and a section dealing with the relatively new topic of pharmacogenetics, as it relates to drug metabolism.
- Emphasises the importance of metabolism throughout the lifetime of the drug development process, bringing together chemical design and optimisation with eventual clinical use.
- Includes many more types of metabolic reactions and interactions than existing publications.
- An emphasis on the understanding of the topics at the molecular level.
- Avoids details of chemical methodology, allowing the reader to focus on the concepts underlying drug delivery optimisation through a knowledge of the principles of biotransformation.
- Provides a new, detailed and accessible presentation of drug-drug interactions and adverse reactions at the molecular level.
- Systematically outlines modern strategies in drug design based primarily on metabolic considerations.
- The treatment of drug design is more comprehensive than previous coverage as it covers all aspects and implications of drug metabolism the authors consider relevant to the target
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Editors and Affiliations
Bibliographic Information
Book Title: Drug Metabolism
Book Subtitle: Current Concepts
Editors: Corina Ionescu, Mino R. Caira
DOI: https://doi.org/10.1007/1-4020-4142-X
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2005
Hardcover ISBN: 978-1-4020-4141-9Published: 28 February 2006
Softcover ISBN: 978-90-481-7058-6Published: 06 November 2010
eBook ISBN: 978-1-4020-4142-6Published: 10 July 2006
Edition Number: 1
Number of Pages: XIV, 422
Topics: Biomedicine general, Pharmacy, Medicinal Chemistry, Pharmacology/Toxicology, Molecular Medicine