Overview
- Editors:
-
-
Pierre Hainaut
-
International Agency for Research on Cancer, World Health Organization, France
-
Klas G. Wiman
-
Cancer Center Karolinska, Karolinska Institute, Sweden
- p53 is considered the most important cancer gene
- p53 is a target for novel cancer therapy strategies already underway
- p53 works as a sensor of oncogenic environmental stress
- Written by world-leading scientists in the p53 field
- Provides a unique summary of the field not available anywhere else
Access this book
Other ways to access
Table of contents (20 chapters)
-
-
- Harlan Robins, Gabriela Alexe, Sandra Harris, A. J. Levine
Pages 1-25
-
- Kristine McKinney, Carol Prives
Pages 27-51
-
- Kevin G. McLure, Michael B. Kastan
Pages 53-71
-
- Geoffrey M. Wahl, Jayne M. Stommel, Kurt Krummel, Mark Wade
Pages 73-113
-
- Lauren Brown, Samuel Benchimol
Pages 115-140
-
- Shulin Wang, Wafik S. El-Deiry
Pages 141-163
-
-
- Lawrence A. Donehower, Dora Bocangel, Melissa Dumble, Guillermina Lozano
Pages 183-207
-
-
- Olimpia Monti, Alexander Damalas, Sabrina Strano, Giovanni Blandino
Pages 223-232
-
- Carlos P. Rubbi, Jo Milner
Pages 233-253
-
-
- Hong Shi, Florence Le Calvez, Magali Olivier, Pierre Hainaut
Pages 293-319
-
- Magali Olivier, Pierre Hainaut, Anne-Lise Børresen-Dale
Pages 321-338
-
- Michael T. Hemann, Scott W. Lowe
Pages 339-351
-
-
- Andreas C. Joerger, Assaf Friedler, Alan R. Fersht
Pages 377-397
-
- Galina Selivanova, Vladimir J. N. Bykov, Klas G. Wiman
Pages 399-419
-
About this book
1. Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. Review arcticles, despite their fundamental role in disseminating knowledge, usually focus only on general mechanisms and do not discuss in detail the many variations that can occur with respect to cell type, particular mutation type, as well as biological activation context. Books such as this one may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
Editors and Affiliations
-
International Agency for Research on Cancer, World Health Organization, France
Pierre Hainaut
-
Cancer Center Karolinska, Karolinska Institute, Sweden
Klas G. Wiman