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Bone Metastasis and Molecular Mechanisms

Pathophysiology

  • Book
  • © 2004

Overview

Editors:
  1. Gurmit Singh

    1. Juravinski Cancer Centre, McMaster University, Hamilton, Canada

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  2. William Orr

    1. Department of Pathology, University of Manitoba, Winnipeg, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • Provides an overview of molecular factors that offer targets and avenues for therapeutic strategies

Part of the book series: Cancer Metastasis - Biology and Treatment (CMBT, volume 6)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model

    • Belinda S. Parker, Bedrich L. Eckhardt, Robin L. Anderson
    Pages 1-18

  3. Quantitation of Bone Metastasis in Experimental Systems

    • Julie A. Sharp, Erik W. Thompson
    Pages 19-30

  4. Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease

    • Snezana Vukmirovic-Popovic, Eric Seidlitz, F. William Orr, Gurmit Singh
    Pages 31-48

  5. Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases

    • Michael H. Weber, Jonathan C. Sharp, Thomas H. Hassard, Martin Reed, James A. Thliveris, F. William Orr
    Pages 49-69

  6. Metastasis in the Bone Marrow Microenvironment

    • Paolo Bianco, Mara Riminucci, Pamela Gehron Robey
    Pages 71-85

  7. The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis

    • Nicholas A. Athanasou
    Pages 87-108

  8. The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease

    • Linda M. Pilarski, Tony Reiman, Patrick M. Pilarski, F. William Orr, Andrew R. Belch
    Pages 109-138

  9. Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking

    • Gabri Van Der Pluijm, Jeroen Buijs
    Pages 139-162

  10. Prostate Cancer: Models for Developing Novel Therapeutic Approaches

    • Shafaat A. Rabbani, Nicholas Shukeir, Andrew P. Mazar
    Pages 163-186

  11. Potential Therapeutic Targets for Bone Metastasis

    • Sadmeet Singh, Gurmit Singh
    Pages 187-210

  12. OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis

    • Paul J. Kostenuik
    Pages 211-240

  13. Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer

    • Wilhelmina C. M. Duivenvoorden, Gurmit Singh
    Pages 241-276

  14. The Role of Bisphosphonates in Bone Metastasis

    • Mary MacKenzie, Pierre Major
    Pages 277-301

  15. Back Matter

    Pages 303-308
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Keywords

About this book

Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.

Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.

Editors and Affiliations

  • Juravinski Cancer Centre, McMaster University, Hamilton, Canada

    Gurmit Singh

  • Department of Pathology, University of Manitoba, Winnipeg, Canada

    William Orr

Bibliographic Information

  • Book Title: Bone Metastasis and Molecular Mechanisms

  • Book Subtitle: Pathophysiology

  • Editors: Gurmit Singh, William Orr

  • Series Title: Cancer Metastasis - Biology and Treatment

  • DOI: https://doi.org/10.1007/978-1-4020-2036-0

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2004

  • Hardcover ISBN: 978-1-4020-1984-5Published: 31 March 2004

  • Softcover ISBN: 978-90-481-6563-6Published: 06 December 2010

  • eBook ISBN: 978-1-4020-2036-0Published: 11 November 2013

  • Series ISSN: 1568-2102

  • Series E-ISSN: 2215-1648

  • Edition Number: 1

  • Number of Pages: XVI, 308

  • Topics: Oncology, Cancer Research, Pathology

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