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Proteases and Their Inhibitors in Cancer Metastasis

  • Book
  • © 2002

Overview

Editors:
  1. Jean-Michel Foidart

    1. Laboratoire de Biologie des Tumeurs et du Développement, Faculté de Médecine Université de Liège, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  2. Ruth J. Muschel

    1. Department of Pathology & Laboratory Medicine, University of Pennsylvania, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Metastasis - Biology and Treatment (CMBT, volume 4)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-vi
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  2. Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction

    • A. Luttun, P. Carmeliet
    Pages 1-22

  3. Role of Serine Proteases and their Inhibitors in Tumor Growth and Angiogenesis

    • A. Noël, J.-M. Foidart
    Pages 23-38

  4. The Gelatinases, MMP-2 and MMP-9-Implications for Invasion and Metastasis

    • Ruth J. Muschel, Jiang Yong
    Pages 39-52

  5. The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis

    • Constance E. Brinckerhoff, Ulrike Benbow, Grant B. Tower
    Pages 53-79

  6. Stromelysin-3, a Particular Member of the Matrix Metalloproteinase Family

    • M.-C. Rio
    Pages 81-107

  7. Membrane-Type Matrix Metalloproteinases

    • Yoshifumi Itoh, Motoharu Seiki
    Pages 109-125

  8. 3D Structure and Drug Design

    • J. Schröder, H. Wenzel, H. Tschesche
    Pages 127-150

  9. Transcriptional Control of Proteases

    • H. Allgayer, E. Lengyel, D. D. Boyd
    Pages 151-168

  10. Tissue Inhibitors of Metalloproteinases in Cancer

    • Yves A. DeClerck
    Pages 169-194

  11. Clinical Aspects of Matrix Metalloproteinases

    • Béatrice Nawrocki-Raby, Christine Clavel, Myriam Polette, Philippe Birembaut
    Pages 195-204

  12. Tissue Models to Study Tumor-Stroma Interactions

    • N. E. Fusenig, M. Skobe, S. Vosseler, M. Hansen, W. Lederle, K. Airola et al.
    Pages 205-223

  13. Mammalian Heparanase: Molecular Properties, Inhibition and Involvement in Tumor Metastasis and Angiogenesis

    • I. Vlodavsky, Y. Friedmann, M. Elkin, O. Pappo, I Pecker, M. D. Hulett et al.
    Pages 225-252

  14. Back Matter

    Pages 253-256
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Keywords

About this book

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account.
This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

Editors and Affiliations

  • Laboratoire de Biologie des Tumeurs et du Développement, Faculté de Médecine Université de Liège, Belgium

    Jean-Michel Foidart

  • Department of Pathology & Laboratory Medicine, University of Pennsylvania, USA

    Ruth J. Muschel

Bibliographic Information

  • Book Title: Proteases and Their Inhibitors in Cancer Metastasis

  • Editors: Jean-Michel Foidart, Ruth J. Muschel

  • Series Title: Cancer Metastasis - Biology and Treatment

  • DOI: https://doi.org/10.1007/1-4020-2008-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-1-4020-0923-5Published: 31 July 2003

  • Softcover ISBN: 978-90-481-6142-3Published: 09 December 2010

  • eBook ISBN: 978-1-4020-2008-7Published: 11 April 2006

  • Series ISSN: 1568-2102

  • Series E-ISSN: 2215-1648

  • Edition Number: 1

  • Number of Pages: VI, 256

  • Topics: Cancer Research, Oncology

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