Chemical Probes in Biology

1. Front Matter

   Pages i-x

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2. Nitric Oxide: A Simple Free Radical with Complex Chemistry and Biology

   • Jason P. Eiserich

   Pages 1-19

3. Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology

   • Oliver Seitz

   Pages 21-33

4. Signal Regulated Gene Expression Mediated by Transcription Factors-Members of AP-1 and ETS/SRF Family Members: Pathways for Potential Therapeutic Intervention

   • Alex Pintzas

   Pages 35-38

5. Biological Activities of the Phosphoinositide Derivatives, the Glycerophosphoinositols

   • Stefania Mariggio’, Beatrice Maria Filippi, Cristiano Iurisci, Daniela Corda

   Pages 39-49

6. Chemical Synthesis of all Naturally Occurring Phosphorylated Inositol Phospholipids

   • Karol S. Bruzik

   Pages 51-62

7. Molecules of the Inositol Phospholipid Pathway — Enzyme Assisted Syntheses

   • P. Andersch, M. Berger, B. Jakob, K. Lange, M. P. Schneider

   Pages 63-81

8. Phosphatidylinositol Specific Phospholipases C: Structure and Mechanism of Action

   • Karol S. Bruzik

   Pages 83-92

9. Epidermal Growth Factor Receptor Signal Trans-Activation

   • Stefan Hart, Andreas Gschwind, Andreas Roidl, Axel Ullrich

   Pages 93-103

10. From Sequence to Consequence: Structural Biology and Rational Drug Design in the Age of Genomics

    • Gregory A. Petsko, Dagmar Ringe

    Pages 105-119

11. Leukocyte-Derived Myeloperoxidase is a Physiological Nitric Oxide and Nitrite Oxidase: Functions Beyond Host Defense

    • Jason P. Eiserich

    Pages 121-135

12. Lipoic Acid, a Metabolic Antioxidant Stimulates the Insulin Signaling Pathway in Adipocytes and Counteracts Oxidative Stress and Age Related Mitochondrial and Cognitive Dysfunction

    • Lester Packer

    Pages 137-144

13. Lipid Peroxidation and Oxidative Stress Induced Etheno- DNA Adducts in Humans and Rodents

    • J. Nair, H. Bartsch

    Pages 145-152

14. Brassinosteroids: A New Role of Steroids as Bio-Signaling Molecules

    • Vladimir Khripach, Vladimir Zhabinskii, Raisa Karnachuk

    Pages 153-165

15. Dopamine Influence on Glutamatergic and Gabaergic Interaction in Neocortex of Awaked Brain

    • V. M. Storozhuk

    Pages 167-180

16. Study of Human Replication Protein a by Photoaffinity Labeling Technique

    • O. I. Lavrik, P. E. Pestryakov, J. K. Nazarkina, S. N. Khodyreva

    Pages 181-192

17. Photoaffinity Probes in Molecular Biology of DNA Replication and DNA Repair

    • O. I. Lavrik, S. N. Khodyreva

    Pages 193-205

18. Neoglycoconjugates as Probes in Glycobiology

    • N. V. Bovin

    Pages 207-225

19. Glycosylphosphatidylinositol Anchors

    • L. M. Thomson, T. Fontaine, A. Mehlert, M. A. J. Ferguson

    Pages 227-233

20. Development of New Synthetic Tools for the Preparation of Biologically Active Molecules

    • Steven V. Ley, Ian R. Baxendale, Peter Grice

    Pages 235-244

This NATO Advanced Study Institute (co-sponsored by FEBS and INTAS) under the title "Chemical Probes in Biology" was designed to summarize and disseminate recent expert knowledge regarding a deeper understanding ofbiological phenomena on a molecular level. Such scientific activities -frequently termed Bio-organic Chemistry or Chemical Biology ­ are constituting a highly interdisciplinary branch of chemistry beyond the traditional ways in which chemists and biologists have been working in the past. Thus, on this occasion we were bringing together senior experts from the disciplines of Chemistry and Biology in order to amalgamate their diverse yet basically common interests in this area. Ultimate goal was - next to an exchange of information between the two scientific cultures - the communication ofexciting possibilities in interdisciplinary research to the young scientists present. The meeting was held in the Anargyros and Korgialenios School on the Island ofSpeteses, Greece from 18-30 August 2002. The ASI was attended by a total of 91 scholars from 23 different countries. A group of 27 speakers presented a series of 34 highly stimulating, informative and educational lectures covering a broad range of topics relevant to the general theme ofthis meeting: Science at the InteifaceofChemistry, Biology and Medicine. The lectures were complemented by a total of 89 posters presented by the young scholars and a series of short lectures derived thereof This was clearly one ofthe highlites of the meeting creating a lively atmosphere of interaction and intellectual creativity - typical phenomena for the whole meeting.

• Chemical synthesis
• DNA
• Oxidation
• biology
• enzymes
• proteins
• therapy

• Organic Chemistry, Bergische Universität Wuppertal, Wuppertal, Germany

  Manfred P. Schneider

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