Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

1. Front Matter

   Pages i-xxii

   PDF

2. Chemical Principles in Reactive Oxygen and Nitrogen Signaling

   1. Redox State and Redox Environment in Biology

      • Freya Q. Schafer, Garry R. Buettner

      Pages 1-14

   2. Sulfur and Selenium Catalysis as Paradigms for Redox Regulations

      • Leopold Flohé

      Pages 15-32

   3. Thiols of Thioredoxin and Glutaredoxin in Redox Signaling

      • Anne Holmgren

      Pages 33-52

   4. Reactivity and Diffusivity of Nitrogen Oxides in Mammalian Biology

      • Jack R. Lancaster Jr.

      Pages 53-79

   5. Bacterial Peroxiredoxins

      • Leslie B Poole

      Pages 80-101

3. Redox Signaling

   1. The Nox Enzymes and the Regulated Generation of Reactive Oxygen Species

      • Rebecca S. Arnold, J. David Lambeth

      Pages 102-118

   2. NO Synthesis and NOS Regulation

      • Ulrich Forstermann, Huige Li, Petra M. Schwarz, Hartmut Kleinert

      Pages 119-154

   3. S-nitrosothiols in Cell Signaling

      • Joseph Loscalzo

      Pages 155-166

   4. Hydrogen Peroxide as Intracellular Messenger: Identification of Protein Tyrosine Phosphatases and Pten as H2O2 Target

      • Sue Goo Rhee, Seung-Rock Lee, Kap-Seok Yang, Jaeyul Kwon, Sang Won Kang

      Pages 167-179

   5. 4-Hydroxynonenal Signaling

      • Giuseppe Poll, Gabriella Leonarduzzi, Elena Charpotto

      Pages 180-193

   6. Ceramide Signaling under Oxidative Stress

      • Tzipora Goldkorn, Tommer Ravid, Edward A Medina

      Pages 194-222

   7. Map Kinases in Redox Signaling

      • Atsushi Matsuzawa, Hideki Nishitoh, Kohsuke Takeda, Hidenori Ichijo

      Pages 223-236

   8. Activation of Prostaglandin Biosynthesis: Peroxynitrite vs Hydroperoxides

      • Lisa Landino

      Pages 237-255

   9. Phylogenetic Conservation of the Nrf2-Keap1 Signaling System

      • Xue Zhang, Gark Garfinkel, Douglas Ruden

      Pages 256-274

4. Physiology and Pathophysiology

   1. The NO-cytochrome C Oxidase Signaling Pathway; Mechanisms and Biological Implications

      • Sruti Shiva, Anna-Liisa Levonen, Maria Cecilia Barone, Victor M. Darley-Usmar

      Pages 275-290

   2. The Concept of Compartmentalization in Signaling by Reactive Oxygen Species

      • Victor J. Thannickal, Barryl Fanburg

      Pages 291-310

   3. Role of Mitochondrial Oxygen and Nitrogen Reactive Species in Signaling

      • Cecilia Giulivi, Merry Jo Oursler

      Pages 311-332

   4. Redox Regulation of Gene Expression: Transcriptional Induction of Heme Oxygenase-1

      • Timothy P. Dalton, Lei He, Howard G. Shertzer, Alvaro Puga

      Pages 333-364

   5. Apoptosis Mechanisms Initiated by Oxidative Stress

      • Irene E Kochevar

      Pages 365-378

Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

• Activation
• Drogen
• Regulation
• biochemistry
• biosynthesis
• conservation
• enzymes
• gene expression
• genes
• hydrogen peroxide
• physiology
• signal transduction
• transcription

• University of Alabama at Birmingham, Birmingham, USA

  Henry Jay Forman

• University of California at Los Angeles, Los Angeles, USA

  Jon Fukuto

• Childrens Hospital Los Angeles Research Institute, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, USA

  Martine Torres

Policies and ethics