Editors:
- Includes cutting-edge methods and protocols
- Provides step-by-step detail essential for reproducible results
- Contains key notes and implementation advice from the experts
Part of the book series: Methods in Molecular Biology (MIMB, volume 2217)
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Table of contents (17 protocols)
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Front Matter
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Integrin Activation and Focal Adhesion Measurements
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Front Matter
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Proximity and Microscopy-Based Methods to Determine Integrin Interactions
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Front Matter
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Biochemical, Proteomics and Computational Methods to Determine Integrin Interactions
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Front Matter
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Biophysical Methods to Determine Integrin Activation and Its Cellular and Molecular Effects
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Front Matter
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Integrin Activation and Interactions in Specific Systems and Processes
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Front Matter
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About this book
This volume provides the most cutting edge technologies related to the study of integrin activation and the characterization of their vast interactomes. Chapters detail protocols on experimental approached to quantify focal adhesion parameters, integrin activation, and the lateral interaction of integrins with transmembrane binding partners. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, The Integrin Interactome: Methods and Protocols aims to give the reader a multi-scale journey from single bonds inside protein structures to the function of these crucial adhesion receptors at a whole organism level in physiology and pathology.
Editors and Affiliations
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Molecular Mechanisms Program, Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Cientóficas (CSIC)-University of Salamanca, Salamanca, Spain
Miguel Vicente-Manzanares
Bibliographic Information
Book Title: The Integrin Interactome
Book Subtitle: Methods and Protocols
Editors: Miguel Vicente-Manzanares
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-0716-0962-0
Publisher: Humana New York, NY
eBook Packages: Springer Protocols
Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021
Hardcover ISBN: 978-1-0716-0961-3Published: 20 November 2020
Softcover ISBN: 978-1-0716-0964-4Published: 20 November 2021
eBook ISBN: 978-1-0716-0962-0Published: 19 November 2020
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIX, 315
Number of Illustrations: 11 b/w illustrations, 43 illustrations in colour
Topics: Cell Biology