Overview
- Editors:
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Wafik S. El-Deiry
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Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia
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Table of contents (39 protocols)
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Understanding the Function and Regulation of Tumor Suppressor Genes
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- Yoichi Taya, Kiichiro Nakajima, Kumiko Yoshizawa-Kumagaye, Katsuyuki Tamai
Pages 17-26
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- Lesley J. Jardine, Carl G. Maki
Pages 27-38
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- Bin-Bing S. Zhou, Michael R. Mattern, Kum Kum Khanna
Pages 39-50
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- Shrihari Kadkol, Jeremy Juang, Tzyy-choou Wu
Pages 51-72
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- Takahiko Kobayashi, Ting Wang, Hua Qian, Rainer K. Brachmann
Pages 73-86
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- Edward C. Thornborrow, Matthew Maurer, James J. Manfredi
Pages 87-100
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- Kumaravel Somasundaram, Sanjeev Das, Smita Lakhotia, Narendra Wajapeyee
Pages 101-116
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- M. Stacey Ricci, Wafik S. El-Deiry
Pages 117-127
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- Timothy K. MacLachlan, Wafik S. El-Deiry
Pages 129-133
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- Sally A. Amundson, Albert J. Fornace Jr.
Pages 141-153
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- E. Robert McDonald III, Wafik S. El-Deiry
Pages 173-185
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- Ruth Hemmer, Wenyi Wei, Annie Dutriaux, John M. Sedivy
Pages 187-206
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- David T. Dicker, Wafik S. El-Deiry
Pages 211-215
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- Timothy K. MacLachlan, Wafik S. El-Deiry
Pages 217-220
About this book
It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.
Reviews
"The book will prove a great help to everybody who would like to enter the field of experimental and or clinical research. Those who are interested in basic understanding microbiology of cancer will enjoy this as well." -Neoplasma
Editors and Affiliations
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Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia
Wafik S. El-Deiry
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Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia
Wafik S. El-Deiry
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Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia
Wafik S. El-Deiry
