Overview
- Editors:
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Duncan F. Rogers
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National Heart and Lung Institute, Imperial College, London, UK
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Louise E. Donnelly
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National Heart and Lung Institute, Imperial College, London, UK
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Table of contents (33 protocols)
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Airway Inflammation and Remodeling in Asthma
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Sample Collection
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- Marina Saetta, Graziella Turato
Pages 19-29
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- Chris Ward, E. Haydn Walters
Pages 31-59
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- Lennart Greiff, Morgan Andersson, Carl G.A. Persson
Pages 61-73
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Sample Collection
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- Margaret M. Kelly, Ann Efthimiadis, Frederick E. Hargreave
Pages 77-91
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- Vera M. Keatings, Julia A. Nightingale
Pages 93-98
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- Paolo Paredi, Sergei A. Kharitonov, Peter J. Barnes
Pages 109-118
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- Johan C. de Jongste, Rijn Jöbsis, H. Rolien Raatgeep
Pages 119-124
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Cell Isolation and Culture
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Front Matter
Pages 125-125
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- Ian R. Witherden, Teresa D. Tetley
Pages 137-146
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- Joachim Seybold, Norbert Suttorp
Pages 147-154
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- Reynold A. Panettieri Jr.
Pages 155-160
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- Bernhard F. Gibbs, Madeleine Ennis
Pages 161-176
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- Leonard W. Poulter, C. M. Burke
Pages 191-203
About this book
Rubor (redness), tumor (swelling), calor (heat), and dolor (pain) are the classical signs of inflammation. These features are obvious in the skin, where injury or disease causes flare, wheal, and painful burning sensations. Vasodi- tation underlies the flare and heat, plasma exudation the swelling, and acti- tion of sensory nerves relays pain. In chronic conditions, skin biopsies show inflammatory cell infiltrate. Inflammation is not unique to the skin and contr- utes to disease and repair processes in other organ systems in the body. From the viewpoint of this volume, lung inflammation is now recognized as central to the pathophysiology of a number of severe respiratory conditions, the two most common being asthma and chronic obstructive pulmonary disease (COPD). In asthma, and to a lesser extent COPD, there is evidence of vasodilatation, with congestion of blood vessels accompanied by reddening of the airway mucosa, and of plasma exudation, leading to swelling of the airway wall. Similarly, although less pronounced than in the skin, there is evidence of pain, for example, the - pleasant chest sensations associated with asthma attacks. Understanding the pat- genesis of airway inflammation will enable rational design of drugs to effectively treat conditions such as asthma and COPD. However, whereas immediate access to the skin facilitates investigation of disease processes, the lung, although “open to atmosphere,” is much less accessible. Consequently, the investigation of lung inflammation is usually indirect. Thus, a wide variety of research techniques are used.
Reviews
"Comprehensive and highly practical, the methods presented in this volume provide today's basic and clinical researchers all the major techniques for investigating airway inflammation, and powerfully illuminate many novel targets for emerging drugs." - Journal of Investigational Allergology and Clinical Immunology
