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High Throughput Screening

Methods and Protocols

  • Book
  • © 2002

Overview

Editors:
  1. William P. Janzen

    1. Amphora Discovery, Research Triangle Park

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Part of the book series: Methods in Molecular Biology (MIMB, volume 190)

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Table of contents (13 protocols)

  1. Front Matter

    Pages i-x
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  2. Design and Implementation of High Throughput Screening Assays

    • Ricardo Macarrón, Robert P. Hertzberg
    Pages 1-29

  3. Configuring Radioligand Receptor Binding Assays for HTS Using Scintillation Proximity Assay Technology

    • John W. Carpenter, Carmen Laethem, Frederick R. Hubbard, Thomas K. Eckols, Melvyn Baez, Don McClure et al.
    Pages 31-49

  4. Homogeneous Techniques for Monitoring Receptor–Ligand Interactions

    • James S. Marks, Douglas S. Burdette, David A. Giegel
    Pages 51-63

  5. Comparison of SPA, FRET, and FP for Kinase Assays

    • Jinzi J. Wu
    Pages 65-85

  6. Electrochemiluminescence: A Technology Evaluation and Assay Reformatting of the Stat6/P578 Protein–Peptide Interaction

    • Robert H. Schweitzer, Laura Abriola
    Pages 87-106

  7. Cellular Assays in HTS

    • Patricia Johnston
    Pages 107-116

  8. Compound Library Management

    • James A. Chan, Juan A. Hueso-Rodríguez
    Pages 117-127

  9. Compound Library Management: An Overview of an Automated System

    • Wilma W. Keighley, Terry P. Wood
    Pages 129-152

  10. Natural Products or Not? How to Screen for Natural Products in the Emerging HTS Paradigm

    • Susan P. Manly, Ramesh Padmanabha, Susan E. Lowe
    Pages 153-168

  11. Introduction to Screening Automation

    • Steven Hamilton
    Pages 169-189

  12. Unit Automation in High Throughput Screening

    • Karl C. Menke
    Pages 195-211

  13. Fully Automated Screening Systems

    • Seth Cohen, Robert F. Trinka
    Pages 213-228

  14. Management and Maintenance of High Throughput Screening Systems

    • Barbara Hynd
    Pages 229-243

  15. Back Matter

    Pages 247-265
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About this book

In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.

Editors and Affiliations

  • Amphora Discovery, Research Triangle Park

    William P. Janzen

Bibliographic Information

  • Book Title: High Throughput Screening

  • Book Subtitle: Methods and Protocols

  • Editors: William P. Janzen

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1385/1592591809

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2002

  • eBook ISBN: 978-1-59259-180-0Published: 05 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 265

  • Number of Illustrations: 26 b/w illustrations, 5 illustrations in colour

  • Topics: Pharmacy

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