Overview
- Editors:
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John M. Walker
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Andrew J. Pollard
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BC Research Institute for Children’s and Women’s Health, Vancouver, Canada
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Martin C. J. Maiden
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Wellcome Trust Centre for the Epidemiology of Infectious Disease, Oxford, UK
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Table of contents (40 protocols)
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Front Matter
Pages i-xvii
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- Malcolm Guiver, Ray Borrow
Pages 23-39
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- Michael A. Sobanski, Rosemary A. Barnes, W. Terence Coakley
Pages 41-59
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- Stephen J. Gray, Ray Borrow, Edward B. Kaczmarski
Pages 61-87
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- Luisa Arreaza, Julio A. Vázquez
Pages 107-119
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- Martin C. J. Maiden, Norman T. Begg
Pages 121-130
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- Betsy Kuipers, Germie van den Dobbelsteen, Elisabeth Wedege, Loek van Alphen
Pages 131-145
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- Mark Achtman, Giovanna Morelli
Pages 147-155
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- Ulrich Vogel, Heike Claus, Matthias Frosch
Pages 187-201
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- Michael P. Jennings, Andrew W. Berrington, E. Richard Moxon
Pages 203-214
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- Alex C. Jeffries, Nigel J. Saunders, Derek W. Hood
Pages 215-230
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- Lucas D. Bowler, Aldert Bart, Arie van der Ende
Pages 231-255
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About this book
Meningococcal septicemia and meningitis continue to be important causes of devastating illness, death, and long-term disability in both developed and resource-poor countries of the world. Few diseases have attracted as much public attention, or are as feared by parents and family members, as well as the medical staff who have to care for affected patients. The unexpected and unp- dictable occurrence of the disease in previously healthy children and young adults, its rapid progression, and the frequent occurrence of purpura fulminans with the resulting gangrene of limbs and digits and the requirement for mutilating s- gery, have all heightened both public and medical interest in the disease. Over the past two decades there has been a rapid increase in knowledge of many aspects of meningococcal disease as a result of intensive efforts by workers in many different fields: clinicians have studied the early presenting features and acute pathophysiology of the disorder; clinical scientists have explored the immunopathological mechanisms responsible for disease and have highlighted the important roles played by the host inflammatory response and pro-inflammatory cytokines in mediating damage to blood vessels and organs; microbiologists have developed new diagnostic methods; public health phy- cians and epidemiologists have improved surveillance techniques with the help of molecular tools provided by bacterial population biologists; and basic sci- tists have used the powerful new tools in molecular and cell biology to elucidate virulence mechanisms.
Reviews
"The editors invited the most skilled specialists in the world, 95 contributors, to share with the readers their knowledge of many aspects of meningococcal disease....The book is a brilliant and comprehensive review of the most recent methods for investigation of meningococcal disease and Neisseria meningitidis. It also includes detailed protocols, which should contribute to standardization of meningococcal investigation in the whole world and should allow different laboratories to obtain comparable results. The book is an excellent source of references. It is highly recommended to microbiologists, epidemiologists and clinicians dealing with meningococcal disease." - Folia Microbiologia
"The book claims to be "a comprehensive and authoritative review of meningococcal biology", "an interdisciplinary survey of recent advances and knowledge", to give "cutting-edge methods for the diagnosis, epidemiology and treatment of meningococcal disease", and it fully meets these standards. It has achieved its aim to join basic science with epidemiological and clinical aspects of the disease." - International Journal of Medical Microbiology
Editors and Affiliations
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BC Research Institute for Children’s and Women’s Health, Vancouver, Canada
Andrew J. Pollard
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Wellcome Trust Centre for the Epidemiology of Infectious Disease, Oxford, UK
Martin C. J. Maiden
