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Immunotoxin Methods and Protocols

  • Book
  • © 2001

Overview

Editors:
  1. Walter A. Hall

    1. Department of Neurosurgery, University of Minnesota, Minneapolis

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Part of the book series: Methods in Molecular Biology (MIMB, volume 166)

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Table of contents (18 protocols)

  1. Front Matter

    Pages i-xi
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  2. Immunotoxin Construction and Development

    1. Front Matter

      Pages 1-1
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    2. Development and Activities of the BR96-Doxorubicin Immunoconjugate

      • Ingegerd Hellström, Karl Erik Hellström, Peter D. Senter
      Pages 3-16

    3. CD7-Specific Single Chain Fv Immunotoxins

      • Christopher A. Pennell, Mary E. Pauza
      Pages 17-29

    4. Recombinant Fusion Toxins Directed Against the Human Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Receptor

      • Yu Shao, Berta E. Warman, John P. Perentesis
      Pages 31-53

    5. Synthesis of Monensin Derivatives and Their Effect on the Activity of Ricin A-Chain Immunotoxins

      • Marco Colombatti, Franco Dosio
      Pages 55-70

    6. Purification and Conjugation of Type 1 Ribosome-Inactivating Proteins

      • Luigi Barbieri, Andrea Bolognesi, Fiorenzo Stirpe
      Pages 71-85

    7. Comparison of Immunotoxins Bearing a Single Saporin Molecule with Multiple Toxin Conjugates

      • David J. Flavell, Sopsamorn U. Flavell
      Pages 87-100

    8. Modulation of Growth Factor Receptor Expression by Irradiation for Immunotoxin Targeting

      • Ki-Uk Kim, Hsiao-Tzu Ni, Stephen R. Spellman, Kwan H. Cho, Walter C. Low, Walter A. Hall
      Pages 101-110

    9. Quantification of Immunotoxin Number for Complete Therapeutic Response

      • Robert J. Kreitman
      Pages 111-123

    10. In Vitro Studies of Ricin A-Chain-Induced Vascular Leak Syndrome

      • Alan L. Lindstrom, Christopher A. Pennell
      Pages 125-135

  3. Oncologic Applications of Immunotoxins

    1. Front Matter

      Pages 136-136
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    2. Immunotoxin Treatment of Brain Tumors

      • Walter A. Hall
      Pages 139-154

    3. Cytotoxins Directed at Interleukin-4 Receptors as Therapy for Human Brain Tumors

      • Raj K. Puri
      Pages 155-176

    4. Bispecific Monoclonal Antibodies for the Targeting of Type I Ribosome-Inactivating Proteins Against Hematological Malignancies

      • Silvano Ferrini, Sabrina Sforzini, Silvana Canevari
      Pages 177-192

    5. Tyrosine Kinase Inhibitors Against EGF Receptor-Positive Malignancies

      • Elise A. Sudbeck, Sutapa Ghosh, Xing-Ping Liu, Yaguo Zheng, Dorothea E. Myers, Fatih M. Uckun
      Pages 193-218

    6. Targeting Tumor Vasculature Using VEGF-Toxin Conjugates

      • S. Ramakrishnan, Robert Wild, Dana Nojima
      Pages 219-234

    7. Gene Therapy With Immunotoxins

      • Daniel A. Vallera
      Pages 235-246

  4. Alternative Applications of Immunotoxins

    1. Front Matter

      Pages 247-247
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    2. Effects of Selective Immunotoxic Lesions on Learning and Memory

      • Mark G. Baxter
      Pages 249-265
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About this book

Immunotoxins represent a new class of human therapeutics that have widespread applications and a potential that has not yet been fully recognized since they were first conceived of by Paul Ehrlich in 1906. The majority of advances in the development and implementation of immunotoxins has occurred over the last 20 years. The reasons for this use of immunotoxins in basic science and clinical research are the powerful concurrent advances in genetic engineering and receptor physiology. Recombinant technology has allowed investigators to produce sufficient quantities of a homogeneous c- pound that allows clinical trials to be performed. The identification of specific receptors on malignant cell types has enabled scientists to generate immunotoxins that have had positive results in clinical trials. As more cellular targets are identified in coming years, additional trials will be conducted in different disease states affecting still larger patient populations. Modulation of the immune system to decrease the humoral response to immunotoxins may improve their overall efficacy. As increasingly more effective compounds are generated, it will be necessary to decrease the local and systemic toxicity - sociated with these agents, and methods for doing so are presently being - veloped. The work presented in Immunotoxin Methods and Protocols focuses on three specific areas of immunotoxin investigation that are being conducted by experts throughout the world. The first section describes the construction and development of a variety of immunotoxins.

Editors and Affiliations

  • Department of Neurosurgery, University of Minnesota, Minneapolis

    Walter A. Hall

Bibliographic Information

  • Book Title: Immunotoxin Methods and Protocols

  • Editors: Walter A. Hall

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1385/1592591140

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2001

  • Hardcover ISBN: 978-0-89603-775-5Published: 22 December 2000

  • Softcover ISBN: 978-1-61737-183-7Published: 10 November 2010

  • eBook ISBN: 978-1-59259-114-5Published: 02 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 297

  • Topics: Immunology

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