Overview
- Editors:
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Susan A. Brooks
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Research School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK
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Udo Schumacher
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Institute for Anatomy, Department of Neuroanatomy, University Hospital Hamburg-Eppendorf, Hamburg, Germany
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Table of contents (21 protocols)
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Detection Methods for Cellular Markers of Metastatic Potential
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- Derek E. Roskell, Ian D. Buley
Pages 3-11
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- Amanda J. Atherton, Catherine Clarke
Pages 41-48
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- Susan A. Brooks, Debbie M.S. Hall
Pages 49-65
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- Stephan Braun, Klaus Pantel
Pages 67-73
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- Lawrence John, Massimo Pignatelli
Pages 75-98
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- Girolamo Ranieri, Giampietro Gasparini
Pages 99-113
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- Christine Blancher, Adam Jones
Pages 145-162
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- Marta Toth, Rafael Fridman
Pages 163-174
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Genetic Aspects of Metastasis
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Front Matter
Pages 175-175
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- Hakan Goker, Janet Shipley
Pages 199-221
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- Adam Jones, Chisato Fujiyama, Kenneth Smith
Pages 241-253
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- Thelma Tennant, Marina Chekmareva, Carrie W. Rinker-Schaeffer
Pages 255-270
About this book
The process of metastasis formation is hugely complex, as described in the introductory chapter of this book, and this complexity has led us to compile two volumes of methods, from a vastly divergent background that attempts to encompass the whole spectrum of cancer biology. This first volume, Metastasis Research Protocols: Analysis of Cells and Tissues, concentrates on analysis and mapping of molecules produced by cells and tissues and analysis of the molecular biology underlying their expression, whereas the second volume, Metastasis Research Protocols: Cell Behavior In Vitro and In Vivo,focuses sharply on the determination of cell behavior in vitro and in vivo. We have deliberately included chapters describing well-established and familiar te- niques (for example, SDS-PAGE and Western blotting [Chapter 11], and immunocytochemistry [Chapter 2]) in addition to the newer and more speci- ized approaches and specific examples of their application, because—although the methodology is readily available in the published literature and established in many laboratories—we wished these volumes to “stand alone” and to make accessible here the standard techniques that underpin much metastasis research for both the newcomer to the field and the seasoned researcher. Undoubtedly, owing to the complexity of the metastatic cascade and the wealth of research techniques involved in scientific approaches to its unraveling, and despite our best efforts to make these volumes as comprehensive as seems feasible, this is a tall order, and there will inevitably be omissions. For these we apologize.
Editors and Affiliations
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Research School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK
Susan A. Brooks
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Institute for Anatomy, Department of Neuroanatomy, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Udo Schumacher
