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Molecular Diagnosis of Cancer

  • Book
  • © 1996

Overview

Editors:
  1. Finbarr E. Cotter

    1. University London, UK

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Part of the book series: Methods in Molecular Medicine (MIMM, volume 6)

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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xiii
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  2. Hematological Malignancies

    1. Front Matter

      Pages 1-1
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    2. PCR of Gene Rearrangements for the Detection of Minimal Residual Disease in Childhood ALL

      • Nick Goulden, Kenneth Langlands, Colin Steward, Chris Knechtli, Mike Potter, Tony Oakhill
      Pages 3-23

    3. Detection of BCR-ABL in Hematological Malignancies by RT-PCR

      • Nicholas C. P. Cross
      Pages 25-36

    4. Molecular Diagnosis of Acute Myeloid Leukemia with Maturation, FAB-Type M2

      • Ewald J. B. M. Mensink, Louis T. F. van de Locht
      Pages 37-45

    5. Analysis of the PML/RAR-α Fusion Gene in Acute Promyelocytic Leukemia by Reverse-Transcription Polymerase Chain Reaction

      • Daniela Diverio, Anna Luciano, Roberta Riccioni, Francesco Lo Coco, Andrea Biondi
      Pages 47-54

    6. RT-PCR Analysis of Breakpoints Involving the MLL Gene Located at 11q23 in Acute Leukemia

      • Chris F. E. Pocock, Finbarr E. Cotter
      Pages 55-62

    7. Polymerase Chain Reaction for Detection of the t(14;18) Translocation in Lymphomas

      • Peter W. M. Johnson
      Pages 63-74

    8. NPM-ALK Reverse Transcriptase-Polymerase Chain Reaction Analysis for Detection of the t(2;5) Translocation of Non-Hodgkin's Lymphoma

      • Sheila A. Shurtleff, James R. Downing, Stephan W. Morris
      Pages 75-89

    9. Molecular Diagnosis of the 5q Deletion in Malignant Myeloid Disorders

      • Jackie Boultwood
      Pages 91-103

    10. Polymerase Chain Reaction Based Methods for Assessing Chimerism Following Allogeneic Bone Marrow Transplantation

      • Mark Lawler, Shaun R. McCann
      Pages 105-120

  3. Solid Tumors

    1. Front Matter

      Pages 121-121
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    2. Identification of Mutations in the Retinoblastoma Gene

      • Annette Hogg
      Pages 123-140

    3. Mutational Analysis of the Wilms' Tumor (WTI) Gene

      • Linda King-Underwood, Kathy Pritchard-Jones
      Pages 141-147

  4. General Techniques for Cancer Analysis

    1. Front Matter

      Pages 149-149
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    2. Single-Strand Conformation Polymorphism Mutation Analysis of the p53 Gene

      • Mark J. Booth
      Pages 151-159

    3. The Characterization of Chromosomal Abnormalities Using Fluorescence In SituHybridization Procedures

      • Helena M. Kempski
      Pages 161-182

    4. Comparative Genomic Hybridization

      • Briana J. Williams
      Pages 183-191

    5. In Situ Hybridization of Cells and Tissue Sections

      • Simon J. Conway
      Pages 193-206

    6. Apoptosis Detection by DNA Analysis

      • Paul D. Allen, Adrian C. Newland
      Pages 207-213
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About this book

The aims of Molecular Diagnosis of Cancer are to introduce scientists and physicians working in the field of diagnostics to the area of cancer molecular pathology and to highlight the possibilities of its application to the cancer physician in the clinic. The degree of molecular biological expertise required should be minimal, although those with more experience may also be able to benefit from the book. All of the authors have considerable practical experience in the method they describe and are working predominantly in the setting of the cancer clinic. As such, the book pulls together a number of te- niques that are already being applied to a wide range of malignancies. Mo- over, this field will continue to expand exponentially as further research leads to a greater understanding of the molecular basis of cancer. Detection of the changes to the DNA or RNA code within a diseased cell often provides pathological information for the diagnosis, prognosis, and m- agement of the disease. Such DNA-related analysis is primarily the role of molecular pathology. Methods to detect these alterations are being refined and are evolving from the research to the diagnostic laboratory. One of the single most powerful techniques in this new branch of pathology has been the polymerase chain reaction (PCR), to which much of this book is devoted.

Reviews

The techniques described here are standard laboratory lore;the added value are the notes and tips on tricky details andoften overlooked precautions....Laboratory scientists...will get their money's worth. -Modern Pathology

The added value are the notes and tips on tricky details and often overlooked precautions. The book will appeal to laboratory scientists. They will get thier money's worth.-University of Kansas School of Medicine

Editors and Affiliations

  • University London, UK

    Finbarr E. Cotter

Bibliographic Information

  • Book Title: Molecular Diagnosis of Cancer

  • Editors: Finbarr E. Cotter

  • Series Title: Methods in Molecular Medicine

  • DOI: https://doi.org/10.1385/0896033414

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 1996

  • eBook ISBN: 978-1-59259-590-7Published: 02 February 2008

  • Series ISSN: 1543-1894

  • Series E-ISSN: 1940-6037

  • Edition Number: 1

  • Number of Pages: XIV, 218

  • Number of Illustrations: 33 b/w illustrations, 8 illustrations in colour

  • Topics: Oncology

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