Animal Models of Neurological Disease, II

1. Front Matter

   Pages i-xviii

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2. Experimental Models of Human Stroke

   • Karen A. Seta, R. Christian Crumrine, Tim S. Whittingham, W. David Lust, David W. McCandless

   Pages 1-50

3. Animal Models of Brain Hypoxia

   • Gary E. Gibson, Hsueh-Meei Huang

   Pages 51-93

4. Animal Models of the Wernicke-Korsakoff Syndrome

   • Maryse Héroux, Roger F. Butterworth

   Pages 95-131

5. Chemically Induced Models of Seizures

   • David W. McCandless, Ross B. FineSmith

   Pages 133-151

6. The Kindling Model of Epilepsy

   • Marc S. Abel, David W. McCandless

   Pages 153-168

7. Genetically Based Animal Models of Seizures

   • David W. McCandless, Marc S. Abel

   Pages 169-182

8. Animal Models of Hepatic Encephalopathies

   • Andres T. Blei, Reed Omarg, Roger F. Butterworth

   Pages 183-222

9. Animal Models for Reye’s Syndrome

   • M. G. Murphy, S. C. Digout, J. F. S. Crocker

   Pages 223-257

10. Animal Models of Niacin-Nicotinamide Deficiency

    • Frederick C. Kauffman

    Pages 259-297

11. Pyridoxine Deficiency

    • Krishnamurti Dakshinamurti, S. K. Sharma, K. J. Lal

    Pages 299-327

12. Animal Models of Hereditary Hyperammonemias

    • Ijaz A. Qureshi

    Pages 329-356

13. Back Matter

    Pages 357-373

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to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.

These books go out of their way to be helpful. Most chapters introduce the animal models against the background of the human (i.e., clinical) context and conclude with a brief summary. Detailed experimental protocols and useful tabulations abound. Descriptions are exhaustive.-Trends in Neurosciences

• University of Saskatchewan, Saskatoon, Canada

  Alan A. Boulton

• University of Alberta, Edmonton, Canada

  Glen B. Baker

• University of Montreal, Montreal, Canada

  Roger F. Butterworth

Policies and ethics