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Mitochondrial Dysfunction in Neurodegenerative Disorders

  • Book
  • © 2012

Overview

Editors:
  1. Amy Katherine Reeve

    1. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Kim Jennifer Krishnan

    1. , Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  3. Michael R. Duchen

    1. , Department of Cell and Developmental Bio, University College London, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  4. Doug M Turnbull

    1. , Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • The book will contain contributions from a number of leading international scientists in the field so that the reader will have access to the most current research in a concise and logical format

  • Will contain schematic diagrams, results images and tables to assist the reader in the understanding of some of the results and discussions of the book

  • Will cover all aspects of the potential contribution of mitochondria to these diseases from the simple to the more complex, both in terms of experimental data and literature review. This will assist the reader in understanding new and perhaps difficult concepts

  • Contains experimental methods and as well as results. Any readers with a similar interest may find methods beneficial to their research interests

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Mitochondrial Function and Genetics

    1. Front Matter

      Pages 1-1
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    2. An Introduction to Mitochondria

      • Amy Katherine Reeve, R. N. Lightowlers
      Pages 3-18

  3. Mitochondrial Dysfunction: Causes and Effects?

    1. Front Matter

      Pages 19-19
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    2. Neurodegeneration in Primary Mitochondrial Disorders

      • Nichola Lax, Evelyn Jaros
      Pages 21-41

    3. Mutations in Nuclear Genes That Affect Mitochondrial Function in Parkinson’s Disease

      • Gavin Charlesworth, Nicholas W. Wood
      Pages 43-61

    4. Common mtDNA Polymorphisms and Neurodegenerative Disorders

      • Joanna L. Elson, David C. Samuels
      Pages 63-78

    5. mtDNA Mutations in Brain Aging and Neurodegeneration

      • Kim Jennifer Krishnan, Amy Katherine Reeve
      Pages 79-91

  4. Functional Consequences of Mitochondrial Dysfunction

    1. Front Matter

      Pages 93-93
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    2. Mitochondrial Dysfunction in Neurodegenerative Disease: Protein Aggregation, Autophagy, and Oxidative Stress

      • Jianhua Zhang, Victor Darley-Usmar
      Pages 95-111

    3. Mitochondria, Sodium, and Calcium in Neuronal Dysfunction

      • David G. Nicholls
      Pages 113-125

    4. Mitochondrial Membrane Potential and Dynamics

      • Jorge M. A. Oliveira
      Pages 127-139

    5. Dysfunction of the Ubiquitin/Proteasome System and Mitochondria in Neurodegenerative Disease

      • Matthew Y. Tang, Douglas A. Gray
      Pages 141-155

    6. Neuronal Mitochondrial Transport and Dysfunction

      • Talia A. Atkin, Andrew F. MacAskill, Josef T. Kittler
      Pages 157-173

    7. Mitochondrial Changes Associated with Demyelination: Consequences for Axonal Integrity

      • Graham Robert Campbell, Kenneth J. Smith, Don J. Mahad
      Pages 175-190

  5. Modeling Mitochondrial Contribution to Neurodegenerative Disease

    1. Front Matter

      Pages 191-191
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    2. Modeling Mitochondrial Dysfunction in Neurodegenerative Disease

      • Johannes C. Komen, David R. Thorburn
      Pages 193-212

  6. The Future

    1. Front Matter

      Pages 213-213
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    2. Potential Therapies for Mitochondrial Dysfunction

      • Claire Henchcliffe, M. Flint Beal
      Pages 215-230

  7. Back Matter

    Pages 231-242
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Keywords

About this book

As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Editors and Affiliations

  • Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

    Amy Katherine Reeve

  • , Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

    Kim Jennifer Krishnan, Doug M Turnbull

  • , Department of Cell and Developmental Bio, University College London, London, United Kingdom

    Michael R. Duchen

Bibliographic Information

  • Book Title: Mitochondrial Dysfunction in Neurodegenerative Disorders

  • Editors: Amy Katherine Reeve, Kim Jennifer Krishnan, Michael R. Duchen, Doug M Turnbull

  • DOI: https://doi.org/10.1007/978-0-85729-701-3

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London Limited 2012

  • eBook ISBN: 978-0-85729-701-3Published: 15 November 2011

  • Edition Number: 1

  • Number of Pages: XXI, 242

  • Number of Illustrations: 8 b/w illustrations, 12 illustrations in colour

  • Topics: Neurology, Medical Biochemistry, Neurosciences, Internal Medicine

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