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Table of contents (10 chapters)
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Front Matter
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Back Matter
Keywords
About this book
The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).
Excitation-Contraction Coupling and Cardiac Contractile Force &endash; Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.
Reviews
W. Jonathan Lederer (excerpted from the Introduction).
`This second edition of a now classical text is both extensively revised and up-to-date. The many illustrations, a large number of which are new to this edition, supplement a clearly written text that is filled with useful information. For those who seek a lucid, comprehensive and authoritative description of the interlocked systems that control the heart beat, I know of no other source that approaches Bers' Excitation-Contraction Coupling and Cardiac Contractile Force.'
Arnold M. Katz
`This book is a breath of fresh (and educated and thoughtful and well-organized) air Don Bers has produced a remarkably approachable and informative volume, clearly superior to others in this field. Active researchers should buy this book for themselves and their students.'
Laurence L. Brunton
Authors and Affiliations
Bibliographic Information
Book Title: Excitation-Contraction Coupling and Cardiac Contractile Force
Authors: Donald M. Bers
Series Title: Developments in Cardiovascular Medicine
DOI: https://doi.org/10.1007/978-94-010-0658-3
Publisher: Springer Dordrecht
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eBook Packages: Springer Book Archive
Copyright Information: Kluwer Academic Publishers 2001
Hardcover ISBN: 978-0-7923-7157-1Published: 31 August 2001
Softcover ISBN: 978-0-7923-7158-8Published: 31 August 2001
eBook ISBN: 978-94-010-0658-3Published: 06 December 2012
Series ISSN: 0166-9842
Edition Number: 2
Number of Pages: XXIV, 427
Topics: Cardiology