Calcium: The molecular basis of calcium action in biology and medicine

1. Front Matter

   Pages i-xxxix

   PDF

2. From Genes to Drugs

   1. From Genes to Drugs

      • Jacques Haiech, Marcel Hibert

      Pages 1-6

3. Basic Mechanisms of Action of Calcium

   1. Front Matter

      Pages 7-7

      PDF

   2. Calcium Signalling in Excitable Cells

      1. Ca2+ Release in Muscle Cells

         • Nathalie Macrez, Jean Mironneau

         Pages 9-25

      2. Calcium Signalling in Neurons Exemplified by Rat Sympathetic Ganglion Cells

         • S. J. Marsh, N. Wanaverbecq, A. A. Selyanko, D. A. Brown

         Pages 27-44

   3. Calcium Signalling in Non-Excitable Cells

      1. Calcium and Platelets

         • J. W. M. Heemskerk

         Pages 45-71

      2. Calcium Signalling in Liver Cells

         • Greg J. Barritt

         Pages 73-94

      3. Intercellular Calcium Signaling in “Non-Excitable” Cells

         • Thierry Tordjmann, Caroline Clair, Michel Claret, Laurent Combettes

         Pages 95-108

      4. The Ca2+-Mobilizing Second Messenger Cyclic ADP-Ribose

         • Andreas H. Guse

         Pages 109-128

      5. Visinin-Like Proteins (VILIPs) — Emerging Role in Cross-Talk between Cellular Signaling Pathways

         • Karl-Heinz Braunewell, Carsten Reissner, Eckart D. Gundefinger

         Pages 129-149

   4. Calcium Signalling in Extracellular Matrix

      1. Calcium Binding to Extracellular Matrix Proteins, Functional and Pathological Effects

         • Alexander W. Koch, Jürgen Engel, Patrik Maurer

         Pages 151-164

      2. The Extracellular Calcium-Sensing Receptor: Molecular Features, Distribution and Its Role in Physiology and Disease

         • Donald T. Ward, Daniela Riccardi

         Pages 165-177

   5. Calcium Storage and Release

      1. Regulation of Inositol 1,4,5-Trisphosphate-Induced Ca2+ Release by Ca2+

         • Jan B. Parys, Ilse Sienaert, Sara Vanlingen, Geert Callewaert, Patrick De Smet, Ludwig Missiaen et al.

         Pages 179-190

      2. Calreticulin and Dynamics of the Endoplasmic Reticulum Lumenal Environment

         • Marek Michalak, Kimitoshi Nakamura, Sylvia Papp, Michal Opas

         Pages 191-204

      3. Ryanodine-Sensitive Calcium Release Channels

         • Daniela Rossi, Virginia Barone, Ilenia Simeoni, Vincenzo Sorrentino

         Pages 205-219

      4. Calcium Inhibition of Cytoplasmic Streaming

         • Hozumi Kawamichi, Akio Nakamura, Kazuhiro Kohama

         Pages 221-244

   6. Calcium and Apoptosis

      1. Penta-EF-Hand (PEF) Proteins and Calsenilin/DREAM: Involvement of the New EF-Hand Calcium-Binding Proteins in Apoptosis and Signal Transduction

         • Masatoshi Maki

         Pages 245-258

      2. Activation of Programmed Cell Death by Calcium: Protection against Cell Death by the Calcium Binding Protein, Calbindin-D28k

         • Sylvia Christakos, Frank Barletta, Michael Huening, Jody Kohut, Mihali Raval-Pandya

         Pages 259-275

   7. Calcium and Cellular Ageing

      1. Calcium and Cellular Ageing

         • Alexej Verkhratsky, Emil Toescu

         Pages 277-286

   8. Calcium and Growth Factor

      1. The Epidermal Growth Factor Receptor and the Calcium Signal

         • Antonio Villalobo, María José Ruano, Paloma I. Palomo-Jiménez, Hongbing Li, José Martín-Nieto

         Pages 287-303

The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world.
The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era.
The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets.
In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches.Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists.
The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

• Calcium
• G proteins
• cells
• growth factor
• microscopy
• molecular mechanisms
• neurons
• platelets
• proteins
• diabetes

• Université Libre de Bruxelles, Belgium

  Roland Pochet

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