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Structural Biology and Functional Genomics

  • Book
  • © 1999

Overview

Editors:
  1. E. Morton Bradbury

    1. Life Sciences Division, Los Alamos National Laboratory, Los Alamos, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Sándor Pongor

    1. Agricultural Biotechnology Centre, Gödöllõ, Hungary

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Partnership Subseries: 3 (ASHT, volume 71)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-ix
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  2. The Skeletal Function of Non-Genic Nuclear DNA: New Evidence from Ancient Cell Chimaeras

    • T. Cavalier-Smith, M. J. Beaton
    Pages 1-18

  3. DNA Repeats in the Human Genome

    • Paolo Catasti, Xian Chen, S. V. Santhana Mariappan, E. Morton Bradbury, Goutam Gupta
    Pages 19-51

  4. Left-Handed Z-DNA: Structure and Function

    • Alan Herbert, Alexander Rich
    Pages 53-72

  5. Superhelical DNA Studied by Solution Scattering and Computer Models

    • Jörg Langowski, Markus Hammermann, Konstantin Klenin, Katalin Tóth
    Pages 73-85

  6. Micro-Mechanical Measurement of the Torsional Modulus of DNA

    • T. R. Strick, D. Bensimon, V. Croquette
    Pages 87-96

  7. Sequence-Dependent Modelling of Local DNA Bending Phenomena: Curvature Prediction and Vibrational Analysis

    • Kristian VlahoviČek, Mircea Gh. Munteanu, Sándor Pongor
    Pages 97-114

  8. Modelling DNA Stretching for Physics and Biology

    • Richard Lavery, Anne Lebrun
    Pages 115-131

  9. Single-Chain 434 Repressors with Altered DNA-Binding Specificities

    • A. Simoncsits, M-L. Tjörnhammar, S. Wang, S. Pongor
    Pages 133-145

  10. Fast Combinatorial Cartography by Fish on Combed Genomic DNA

    • David Bensimon
    Pages 147-149

  11. RNA Folding and Catalysis

    • David M. J. Lilley
    Pages 151-165

  12. Histone-DNA Contacts in Structure/Function Relationships of Nucleosomes as Revealed by Crosslinking

    • Sergei I. Usachenko, E. Morton Bradbury
    Pages 167-189

  13. The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression

    • Memmo Buttinelli, Gianna Panetta, Daniela Rhodes, Andrew Travers
    Pages 191-204

  14. Chromatin Control of HIV-1 Gene Expression

    • Giuseppe Marzio, Mauro Giacca
    Pages 205-216

  15. Mechanisms of Separation of the Complementary Strands of DNA During Replication

    • A. I. Alexandrov, N. R. Cozzarelli, V. F. Holmes, A. B. Khodursky, B. J. Peter, L. Postow et al.
    Pages 217-233

  16. Exploring Structure Space

    • Thomas C. Terwilliger, Joel Berendzen
    Pages 235-249

  17. The Protein Data Bank

    • J. L. Sussman, E. E. Abola, D. Lin, J. Jiang, N. O. Manning, J. Prilusky
    Pages 251-264

  18. Functional Genomics and Enzyme Evolution

    • M. Y. Galperin, E. V. Koonin
    Pages 265-283

  19. The Beamlines of Elettra and Their Application to Structural Biology

    • F. Zanini, A. Lausi, A. Savoia
    Pages 285-301

  20. Back Matter

    Pages 303-313
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Keywords

About this book

Biomedical research will be revolutionised by the current efforts to sequence the human genome and the genomes of model organisms. Of the newly sequenced genes, 50% code for proteins of unknown functions, while as little as 5% of sequences in mammalian genomes code for proteins. New, genome-wide approaches are needed to draw together the knowledge that is emerging simultaneously in a number of fields of genome research.
This volume is a high-level survey of the newly emerging concepts of structural biology and functional genomics for biologists, biochemists and medical researchers interested in genome research. Topics included are chromosome and chromatin organisation, novel DNA and RNA structures, DNA flexibility, supercoiling, prediction of protein functions, strategies for large scale structural analysis, and computer modelling.

Editors and Affiliations

  • Life Sciences Division, Los Alamos National Laboratory, Los Alamos, USA

    E. Morton Bradbury

  • Agricultural Biotechnology Centre, Gödöllõ, Hungary

    Sándor Pongor

Bibliographic Information

  • Book Title: Structural Biology and Functional Genomics

  • Editors: E. Morton Bradbury, Sándor Pongor

  • Series Title: NATO Science Partnership Subseries: 3

  • DOI: https://doi.org/10.1007/978-94-011-4631-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1999

  • Hardcover ISBN: 978-0-7923-5781-0Published: 31 August 1999

  • Softcover ISBN: 978-0-7923-5782-7Published: 31 August 1999

  • eBook ISBN: 978-94-011-4631-9Published: 06 December 2012

  • Series ISSN: 1388-6576

  • Edition Number: 1

  • Number of Pages: IX, 313

  • Topics: Gene Function, Medicine/Public Health, general, Genetic Engineering

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