Skip to main content
SpringerLink
Log in

Apoptosis in Cardiac Biology

  • Book
  • © 2000

Overview

Editors:
  1. Heribert Schunkert

    1. University of Regensburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. G. A. J. Riegger

    1. University of Regensburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Basic Science for the Cardiologist (BASC, volume 5)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (24 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Basic Mechanisms of Apoptosis

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. The initiation of apoptosis

      1. Death receptors and their ligands
        • Jürgen Holtz, Dorothea Darmer
        Pages 5-28
      2. Regulation of apoptosis by CD 137
        • Herbert Schwarz
        Pages 29-37
      3. Reactive oxygen species and apoptosis
        • Rüdiger von Harsdorf
        Pages 39-58

    3. The mediators of apoptosis

      1. Oncogenes and p53
        • Franz Kohlhuber, Dirk Eick
        Pages 61-69
      2. BCL-2 family members and mitochondria
        • Klaus Schlottmann, Jürgen Schölmerich
        Pages 71-90
      3. Inhibition of cardiac myocyte apoptosis by gp130-dependent cytokines
        • Kai C. Wollert
        Pages 91-99
      4. Cell cycle regulation and apoptotic cell death
        • Lothar Jahn, Harald Bär
        Pages 101-108

    4. The execution of apoptosis

      1. Caspase cascades and caspase targets
        • Thomas Rudel
        Pages 111-121
      2. Apoptosis: a distinctive form of cell death
        • L. B. Jordan, D. J. Harrison
        Pages 123-135

  3. Cellular Targets in the cardiovascular system

    1. Front Matter

      Pages 137-137
      Download chapter PDF

    2. Blood vessels

      1. Apoptosis and cell cycle in endothelial cells
        • Ioakim Spyridopoulos
        Pages 141-156

    3. Myocardium

      1. Endurance under stress and cardioprotective functions by cardiac fibroblasts
        • Mahboubeh Eghbali-Webb
        Pages 159-174
      2. Cardiac myocytes
        • Armin Haunstetter, Markus Haass, Seigo Izumo
        Pages 175-188
      3. Cardiac myocytes and fibroblasts exhibit differential sensitivity to apoptosis-inducing stimuli
        • Edward G. Lakatta, Xilin Long, Alan Chesley, Michael Crow
        Pages 189-208

  4. Apoptosis in Cardiac Disorders

    1. Front Matter

      Pages 209-209
      Download chapter PDF

    2. Vascular disease

      1. Hypertension as a cardiovascular proliverative disorder
        • Denis deBlois, Sergei Orlov, Pavel Harnet
        Pages 213-222
      2. Apoptosis in human atherosclerosis
        • Gerhard Bauriedel, Randolph Hutter, Ulrich Welsch, Berndt Lüderitz
        Pages 223-236

    3. Cardiac disease

      1. Apoptosis in myocardial infarction
        • Andreas V. Sigel, Günter A. J. Riegger
        Pages 239-259
Back to top

Keywords

About this book

Apoptosis or programmed cell death is increasingly considered to be a major factor in the development and progression of cardiovascular disease. In patients with heart failure the activation of apoptosis may result in the loss of irreplaceable cardiac myocytes promoting the clinical course of the syndrome. Moreover, in the coronary arteries inflammation and apoptosis may weaken critical structures of the vessel wall leading to plaque rupture and, subsequently, to myocardial infarction. Given these deleterious consequences, it seems almost paradoxical that programmed cell death is an active process that, if initiated under physiological circumstances, is essential for both coordinated tissue growth or destruction of malignant cells.
Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart. The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in vascular smooth muscle and endothelial cells. Furthermore, novel therapeutic options arising from the outstanding pathophysiological significance of cardiac apoptosis are presented.
This comprehensive review of Apoptosis in Cardiac Biology will be of interest to both clinicians and basic researchers who are active in the fields of cardiology and atherosclerosis.

Editors and Affiliations

  • University of Regensburg, Germany

    Heribert Schunkert, G. A. J. Riegger

Bibliographic Information

  • Book Title: Apoptosis in Cardiac Biology

  • Editors: Heribert Schunkert, G. A. J. Riegger

  • Series Title: Basic Science for the Cardiologist

  • DOI: https://doi.org/10.1007/b102337

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-7923-8648-3Published: 30 November 1999

  • Softcover ISBN: 978-1-4757-8262-2Published: 24 March 2013

  • eBook ISBN: 978-0-585-38143-5Published: 30 June 2007

  • Series ISSN: 1566-0753

  • Edition Number: 1

  • Number of Pages: XIV, 354

  • Topics: Cardiology, Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation