Cytokines, Stress, and Depression

1. Front Matter

   Pages i-x

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2. Depression and Immunity

   1. Immune Correlates of Depression

      • Michael Irwin

      Pages 1-24

   2. Major Depression and Activation of The Inflammatory Response System

      • Michael Maes

      Pages 25-46

   3. Cytokine Production in Depressed Patients

      • Andreas Seidel, Matthias Rothermundt, Lothar Rink

      Pages 47-57

   4. Indicators of Immune Activation in Depressed Patients

      • Anna Sluzewska

      Pages 59-73

3. Brain Effects on Cytokines

   1. Mood and Cognitive Disorders in Cancer Patients Receiving Cytokine Therapy

      • Christina A. Meyers

      Pages 75-81

   2. Mechanisms of the Behavioural Effects of Cytokines

      • Robert Dantzer, Arnaud Aubert, Rose-Marie Bluthé, Gilles Gheusi, Sandrine Cremona, Sophie Layé et al.

      Pages 83-105

   3. Effects of Cytokines on Glucocorticoid Receptor Expression And Function

      • Andrew H. Miller, Carmine M. Pariante, Bradley D. Pearce

      Pages 107-116

   4. Effects of Cytokines on Cerebral Neurotransmission

      • Adrian J. Dunn, Jianping Wang, Tetsuya Ando

      Pages 117-127

   5. Inflammation and Brain Function under Basal Conditions and During Long-Term Elevation of Brain Corticotropin-Releasing Hormone Levels

      • Astrid C. E. Linthorst, Johannes M. H. M. Reul

      Pages 129-152

4. Effects of Stress on Cytokine Production and Actions

   1. Dynamic Regulation of Proinflammatory Cytokines

      • Linda R. Watkins, Kien T. Nguyen, Jacqueline E. Lee, Steven F. Maier

      Pages 153-178

   2. Cross-Sensitization Between Immune And Non-Immune Stressors

      • J. H. Tilders, E. D. Schmidt

      Pages 179-197

5. Effects of Cytokines and Cytokine Antagonists in Animal Models of Depression

   1. Anhedonic and Anxiogenic Effects of Cytokine Exposure

      • Hymie Anisman, Zul Merali

      Pages 199-233

   2. Stress, Learned Helplessness, and Brain Interleukin-1β

      • Steven F. Maier, Kien T. Nguyen, Terrence Deak, Erin D. Milligan, Linda R. Watkins

      Pages 235-249

   3. Stress, Depression, and The Role of Cytokines

      • B. E. Leonard, Cai Song

      Pages 251-265

6. Effects of Antidepressants Cytokine Production and Action

   1. Is There Evidence for an Effect of Antidepressant Drugs on Immune Function?

      • Pierre J. Neveu, Nathalie Castanon

      Pages 267-281

   2. Cytokines, “Depression Due to A General Medical Condition,” and Antidepressant Drugs

      • Raz Yirmiya, Joseph Weidenfeld, Yehuda Pollak, Michal Morag, Avraham Morag, Ronit Avitsur et al.

      Pages 283-316

   3. Cytokines, Stress, and Depression

      • Robert Dantzer, Emmanuelle E. Wollman, Ljubisa Vitkovic, Raz Yirmiya

      Pages 317-329

   4. Correction to: Cytokines, “Depression Due to A General Medical Condition,” and Antidepressant Drugs

      • Robert Dantzer, Emmanuelle E. Wollman, Raz Yirmiya

      Pages C1-C1

7. Back Matter

   Pages 331-336

   PDF

Cytokines had been characterized in the early eighties as communication mole­ cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

• behavior
• brain
• cancer
• cytokine
• depression
• inflammation
• neuroscience
• pathophysiology
• physiology
• receptor
• research
• resistance
• stress

• INRA-INSERM, Bordeaux, France

  Robert Dantzer

• CNRS, Paris, France

  Emmanuelle E. Wollman

• The Hebrew University of Jerusalem, Jerusalem, Israel

  Raz Yirmiya

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