Overview
- Editors:
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Robert Dantzer
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INRA-INSERM, Bordeaux, France
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Emmanuelle E. Wollman
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CNRS, Paris, France
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Raz Yirmiya
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The Hebrew University of Jerusalem, Jerusalem, Israel
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Table of contents (18 chapters)
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Depression and Immunity
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- Andreas Seidel, Matthias Rothermundt, Lothar Rink
Pages 47-57
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Brain Effects on Cytokines
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- Robert Dantzer, Arnaud Aubert, Rose-Marie Bluthé, Gilles Gheusi, Sandrine Cremona, Sophie Layé et al.
Pages 83-105
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- Andrew H. Miller, Carmine M. Pariante, Bradley D. Pearce
Pages 107-116
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- Adrian J. Dunn, Jianping Wang, Tetsuya Ando
Pages 117-127
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- Astrid C. E. Linthorst, Johannes M. H. M. Reul
Pages 129-152
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Effects of Stress on Cytokine Production and Actions
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- Linda R. Watkins, Kien T. Nguyen, Jacqueline E. Lee, Steven F. Maier
Pages 153-178
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- J. H. Tilders, E. D. Schmidt
Pages 179-197
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Effects of Cytokines and Cytokine Antagonists in Animal Models of Depression
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- Hymie Anisman, Zul Merali
Pages 199-233
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- Steven F. Maier, Kien T. Nguyen, Terrence Deak, Erin D. Milligan, Linda R. Watkins
Pages 235-249
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Effects of Antidepressants Cytokine Production and Action
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- Pierre J. Neveu, Nathalie Castanon
Pages 267-281
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- Raz Yirmiya, Joseph Weidenfeld, Yehuda Pollak, Michal Morag, Avraham Morag, Ronit Avitsur et al.
Pages 283-316
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- Robert Dantzer, Emmanuelle E. Wollman, Ljubisa Vitkovic, Raz Yirmiya
Pages 317-329
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- Robert Dantzer, Emmanuelle E. Wollman, Raz Yirmiya
Pages C1-C1
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Back Matter
Pages 331-336
About this book
Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.
Editors and Affiliations
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INRA-INSERM, Bordeaux, France
Robert Dantzer
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CNRS, Paris, France
Emmanuelle E. Wollman
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The Hebrew University of Jerusalem, Jerusalem, Israel
Raz Yirmiya