Blood Cell Biochemistry

1. Front Matter

   Pages i-xxiii

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2. The Hematopoietic Cytokine Receptors

   • Anne-Marie O’Farrell, Taisei Kinoshita, Atsushi Miyajima

   Pages 1-40

3. Interleukin 13 and Related Cytokines

   • Andrew N. J. McKenzie, Andrew W. Heath

   Pages 41-50

4. The Tumor-Necrosis-Factor-Related Superfamily of Ligands and Receptors

   • David Cosman

   Pages 51-77

5. Cellular Signaling Events in B Lymphocytes

   • Margaret M. Harnett

   Pages 79-98

6. Cellular and Molecular Aspects of Myeloid Cell Proliferation and Development

   • Caroline A. Evans, Andrew Pierce

   Pages 99-120

7. Myelosuppressive Cytokines and Peptides

   • Hal E. Broxmeyer

   Pages 121-150

8. Apoptosis in Hematopoiesis and Leukemogenesis

   • Rachel S. Chapman, Christopher D. Gregory, Caroline Dive

   Pages 151-201

9. Human T-Cell Differentiation and Cytokine Regulation

   • Mike Salmon, Darrell Pilling, Clair Mappin, Arne N. Akbar

   Pages 203-215

10. Hematopoietic Growth Factors Involved in B-Cell Development

    • Ana Cumano, Barbara L. Kee, Isabelle Godin, Françoise Dieterlen-Lièvre, C. J. Paige

    Pages 217-239

11. Regulation of Peripheral B-Cell Growth and Differentiation

    • Jacques Banchereau, Pierre Garrone, Yong-Jun Liu

    Pages 241-262

12. In Vitro Regulation of Dendritic Cell Development and Function

    • Christophe Caux, Jacques Banchereau

    Pages 263-301

13. Responses of Leukemia Cells to Hematopoietic Growth Factors

    • Ivo P. Touw, Fan Dong

    Pages 303-319

14. The Role of Interleukin 5 in the Production and Function of Eosinophils

    • Jan Tavernier, Geert Plaetinck, Yves Guisez, Jose van der Heyden, Johan Kips, Renaat Peleman et al.

    Pages 321-361

15. Stem Cell Factor

    • Ian K. McNiece, Robert A. Briddell

    Pages 363-379

16. Clinical Use of Myeloid Growth Factors

    • Andrew Weaver, Nydia G. Testa

    Pages 381-413

17. Back Matter

    Pages 415-419

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Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon­ strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down­ stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog­ ical situations (see below).

• T cell
• apoptosis
• biochemistry
• blood
• cell
• cytokine
• cytokines
• hematopoiesis
• immune system
• leukemia
• lymphocytes
• receptor
• stem cell

`Thoroughly recommended as a valuable source of information for a variety of specialists.'
Comparative Haematology International, 1997

• Leukaemia Research Fund Cellular Development Unit, UMIST, Manchester, England

  Anthony D. Whetton

• The Medical School, University of Birmingham, Birmingham, England

  John Gordon

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