Non-Neutral Evolution

1. Front Matter

   Pages i-xii

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2. Alternatives to the Neutral Theory

   • John H. Gillespie

   Pages 1-17

3. Patterns of Polymorphism and Between Species Divergence in the Enzymes of Central Metabolism

   • Walter F. Eanes

   Pages 18-28

4. Molecular Population Genetics in Drosophila Pseudoobscura: Three Future Directions

   • Stephen W. Schaeffer

   Pages 29-45

5. Selection, Recombination, and DNA Polymorphism in Drosophila

   • Charles F. Aquadro, David J. Begun, Eric C. Kindahl

   Pages 46-56

6. Effects of Genetic Recombination and Population Subdivision on Nucleotide Sequence Variation in Drosophila ananassae

   • Wolfgang Stephan

   Pages 57-66

7. Polymorphism and Divergence in Regions of Low Recombination in Drosophila

   • Montserrat Aguadé, Charles H. Langley

   Pages 67-76

8. Inferring Selection and Mutation from DNA Sequences: The McDonald-Kreitman Test Revisited

   • Stanley A. Sawyer

   Pages 77-87

9. Detecting Natural Selection by Comparing Geographic Variation in Protein and DNA Polymorphisms

   • John H. McDonald

   Pages 88-100

10. A Neutrality Test for Continuous Characters Based on Levels of Intraspecific Variation and Interspecific Divergence

    • Andrew G. Clark

    Pages 101-111

11. Estimation of Population Parameters and Detection of Natural Selection from DNA Sequences

    • Wen-Hsiung Li, Yun-Xin Fu

    Pages 112-125

12. Using Maximum Likelihood to Infer Selection from Phylogenies

    • Brian Golding

    Pages 126-139

13. Gene Trees with Background Selection

    • Richard R. Hudson, Norman L. Kaplan

    Pages 140-153

14. Phylogenetic Analysis on the Edge: The Application of Cladistic Techniques at the Population Level

    • Robert DeSalle, Alfried P. Vogler

    Pages 154-174

15. The Divergence of Halophilic Superoxide Dismutase Gene Sequences: Molecular Adaptation to High Salt Environments

    • Patrick P. Dennis

    Pages 175-187

16. Mitochondrial Haplotype Frequencies in Oysters: Neutral Alternatives to Selection Models

    • Andrew T. Beckenbach

    Pages 188-198

17. Gene Duplication, Gene Conversion and Codon Bias

    • Donal A. Hickey, Shaojiu Wang, Charalambos Magoulas

    Pages 199-207

18. Genealogical Portraits of Speciation in the Drosophila melanogaster Species Complex

    • Jody Hey, Richard M. Kliman

    Pages 208-216

19. Genetic Divergence, Reproductive Isolation and Speciation

    • Rama S. Singh, Ling-Wen Zeng

    Pages 217-232

20. Polymorphism at Mhc Loci and Isolation by the Immune System in Vertebrates

    • Naoyuki Takahata

    Pages 233-246

All organisms--from the AIDS virus, to bacteria, to fish, to humans--must evolve to survive. Despite the central place of evolution within biology, there are many things that are still poorly understood. For Charles Darwin, the driving force behind all evolution was natural selection. More recently, evolutionary biologists have considered that many mutations are essentially neutral with respect to natural selection. Many questions remain. Are molecular differences between species adaptive? Are differences within species adaptive? Modern biotechnology has enabled us to identify precisely the actual DNA structure from many individuals within a population, and thus to see how these DNA sequences have changed over time and to answer some of these questions. At the same time, this knowledge poses new challenges to our ability to understand the observed patterns. This exciting volume outlines the biological problems, provides new perspectives on theoretical treatments of the consequences of natural selection, examines the consequences of molecular data, and relates molecular events to speciation. Every evolutionary biologist will find it of interest.

• Adaptation
• Charles Darwin
• DNA
• Darwin
• Evolution
• Klima
• Phylogenie
• Viren
• environment
• enzymes
• genes
• genetics

There is also a healthy mix of novel and established which broadens its appeal. - Heredity

• Department of Biology, McMaster University, Hamilton, Canada

  Brian Golding

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