Peptide Growth Factors and Their Receptors I

1. Front Matter

   Pages I-XXVIII

   PDF

2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. The Multifunctional Nature of Peptide Growth Factors

      • M. B. Sporn, A. B. Roberts

      Pages 3-15

   3. Isolation and Characterization of Growth Factors

      • R. A. Bradshaw, K. P. Cavanaugh

      Pages 17-36

   4. Properties and Regulation of Receptors for Growth Factors

      • M. P. Czech, K. B. Clairmont, K. A. Yagaloff, S. Corvera

      Pages 37-65

3. Individual Growth Factors and Their Receptors

   1. Front Matter

      Pages 67-67

      PDF

   2. The Epidermal Growth Factor Family

      • G. Carpenter, M. I. Wahl

      Pages 69-171

   3. Platelet-Derived Growth Factor

      • E. W. Raines, D. F. Bowen-Pope, R. Ross

      Pages 173-262

   4. Insulin-Like Growth Factors

      • M. M. Rechler, S. P. Nissley

      Pages 263-367

   5. Fibroblast Growth Factors

      • A. Baird, P. Böhlen

      Pages 369-418

   6. The Transforming Growth Factor-βs

      • A. B. Roberts, M. B. Sporn

      Pages 419-472

   7. Interleukin-1

      • J. A. Schmidt, M. J. Tocci

      Pages 473-521

   8. Interleukin-2

      • M. Hatakeyama, T. Taniguchi

      Pages 523-540

   9. Interleukin-3

      • J. N. Ihle

      Pages 541-575

   10. Interleukin-4

       • T. Yokota, N. Arai, K.-I. Arai, A. Zlotnik

       Pages 577-607

   11. Interleukin-5

       • T. Honjo, K. Takatsu

       Pages 609-632

   12. Interleukin-6

       • T. Hirano, T. Kishimoto

       Pages 633-665

   13. Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor)

       • C. J. Sherr, E. R. Stanley

       Pages 667-698

   14. Granulocyte Colony-Stimulating Factor

       • S. Nagata

       Pages 699-722

   15. Granulocyte-Macrophage Colony-Stimulating Factor

       • A. W. Burgess

       Pages 723-745

This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entire field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost impossible for anyone person to stay informed on this subject by reading the primary literature. At the same time it is becoming increasingly apparent that these of universal importance in biology and medicine and that the substances are original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony­ stimulating factors," was quite artifactual; they are in fact the basis of a com­ mon language for intercellular communication. As a set they affect essentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research. This treatise is divided into four main sections. After three introductory chapters, its principal focus is the detailed description of each of the major peptide growth factors in 26 individual chapters.

• Insulin
• Prostaglandin
• antigen
• autoimmune disease
• biochemistry
• chemistry
• cytokine
• growth factor
• metabolism
• mutagenesis
• oncogenes
• pharmacology
• physiology
• research
• steroids

• Laboratory of Chemoprevention, National Cancer Institute, Bethesda, USA

  Michael B. Sporn, Anita B. Roberts

Policies and ethics