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Oncogenes

An Introduction to the Concept of Cancer Genes

  • Book
  • © 1988

Overview

Authors:
  1. Kathy B. Burck

    1. Kasier Foundation Hospital, San Francisco, USA

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  2. Edison T. Liu

    1. Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, USA

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    You can also search for this author in PubMed   Google Scholar

  3. James W. Larrick

    1. GENELABS, Inc., Redwood City, USA
      Psoriasis Research Scientist, Stanford, USA

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    You can also search for this author in PubMed   Google Scholar

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Introduction

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 1-3

  3. Assays: Tools of the New Biology

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 4-37

  4. Viruses and Oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 38-66

  5. Human T Cell Lymphotropic/Leukemia Viruses

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 67-77

  6. Cellular Proto-oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 78-97

  7. Oncogenes and Human Cancers

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 98-132

  8. src and Related Protein Kinases

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 133-155

  9. Growth Factors and Receptors

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 156-181

  10. ras Family of Oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 182-197

  11. myc and Other Nuclear Oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 198-221

  12. Additional Oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 222-233

  13. Transgenic Mice: Direct In Vivo Assay for Oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 234-240

  14. Potential Diagnostic Uses of Oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 241-261

  15. Potential Therapeutic Applications of Oncogenes

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 262-278

  16. Oncogene Paradigm: Contribution to a Fundamental Understanding of Malignancy

    • Kathy B. Burck, Edison T. Liu, James W. Larrick
    Pages 279-280

  17. Back Matter

    Pages 281-300
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Keywords

About this book

"Cancer viruses" have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat­ form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers.

Authors and Affiliations

  • Kasier Foundation Hospital, San Francisco, USA

    Kathy B. Burck

  • Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, USA

    Edison T. Liu

  • GENELABS, Inc., Redwood City, USA

    James W. Larrick

  • Psoriasis Research Scientist, Stanford, USA

    James W. Larrick

Bibliographic Information

  • Book Title: Oncogenes

  • Book Subtitle: An Introduction to the Concept of Cancer Genes

  • Authors: Kathy B. Burck, Edison T. Liu, James W. Larrick

  • DOI: https://doi.org/10.1007/978-1-4612-3718-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1988

  • Softcover ISBN: 978-0-387-96423-2Published: 17 May 1988

  • eBook ISBN: 978-1-4612-3718-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XV, 300

  • Number of Illustrations: 33 b/w illustrations, 4 illustrations in colour

  • Topics: Oncology, Human Genetics, Virology, Pathology

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