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The Sticky Synapse

Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance

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  • © 2009

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Editors:
  1. Hisashi Umemori
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    You can also search for this editor in PubMed   Google Scholar

  2. Michael Hortsch
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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. A Short History of the Synapse – Golgi Versus Ramón y Cajal

    • Michael Hortsch
    Pages 1-9

  3. Cell Adhesion Molecules at the Drosophila Neuromuscular Junction

    • Franklin A. Carrero-Martínez, Akira Chiba
    Pages 11-37

  4. Development of the Vertebrate Neuromuscular Junction

    • Michael A. Fox
    Pages 39-84

  5. Synapse Formation in the Mammalian Central Nervous System

    • Masahiro Yasuda, Hisashi Umemori
    Pages 85-106

  6. Developmental Axonal Pruning and Synaptic Plasticity

    • Bibiana Scelfo, Mario Rosario Buffelli
    Pages 107-140

  7. Cell Adhesion Molecules in Synaptopathies

    • Thomas Bourgeron
    Pages 141-158

  8. The Cadherin Superfamily in Synapse Formation and Function

    • Andrew M. Garrett, Dietmar Schreiner, Joshua A. Weiner
    Pages 159-183

  9. Nectins and Nectin-Like Molecules in the Nervous System

    • Hideru Togashi, Hisakazu Ogita, Yoshimi Takai
    Pages 185-206

  10. The Down Syndrome Cell Adhesion Molecule

    • Hitesh Kathuria, James C. Clemens
    Pages 207-222

  11. Molecular Basis of Lamina-Specific Synaptic Connections in the Retina: Sidekick Immunoglobulin Superfamily Molecules

    • Y. Kate Hong, Masahito Yamagata
    Pages 223-234

  12. SYG/Nephrin/IrreC Family of Adhesion Proteins Mediate Asymmetric Cell–Cell Adhesion in Development

    • Kang Shen
    Pages 235-245

  13. L1-Type Cell Adhesion Molecules: Distinct Roles in Synaptic Targeting, Organization, and Function

    • Smitha Babu Uthaman, Tanja Angela Godenschwege
    Pages 247-263

  14. Cell Adhesion Molecules of the NCAM Family and Their Roles at Synapses

    • Sylwia Owczarek, Lars V. Kristiansen, Michael Hortsch, Peter S. Walmod
    Pages 265-299

  15. MHC Class I Function at the Neuronal Synapse

    • Sebastian Thams, Staffan Cullheim
    Pages 301-319

  16. Pathfinding Molecules Branch Out: Semaphorin Family Members Regulate Synapse Development

    • Suzanne Paradis
    Pages 321-331

  17. Ephrins and Eph Receptor Tyrosine Kinases in Synapse Formation

    • Catherine E. Krull, Daniel J. Liebl
    Pages 333-345

  18. Neurexins and Neuroligins: A Synaptic Code for Neuronal Wiring That Is Implicated in Autism

    • Alexander A. Chubykin
    Pages 347-365

  19. Synaptic Adhesion-Like Molecules (SALMs)

    • Philip Y. Wang, Robert J. Wenthold
    Pages 367-383

  20. The Role of Integrins at Synapses

    • Devi Majumdar, Donna J. Webb
    Pages 385-395
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Keywords

About this book

The molecular mechanisms, which are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions. As synapses present specialized cellular junctions between neurons and their target cells, it may not come as a surprise that neural cell adhesion molecules (CAMs) are of special importance for the genesis and the maintenance of synaptic connections. Genes encoding adhesive molecules make up a significant portion of the human genome, and neural CAMs even have been postulated to be a major factor in the evolution of the human brain. These are just some of the many reasons why we thought a book on neural CAMs and their role in establishing and maintaining neuronal synapses would be highly appropriate for summarizing our current state of knowledge. Without question, over the near future, additional adhesive proteins will join the ranks of synaptic CAMs and our knowledge, and how these molecules enable neurons and their targets to communicate effectively will grow.

About the authors

Dr. Michael Hortsch holds a Diploma degree in Biochemistry from the Free University Berlin and a Ph.D. in Biology from the University of Heidelberg in Germany. While working at the Weizmann Institute in Israel, the European Molecular Biology Laboratory in Heidelberg, and at the University of California at Berkeley he has published on topics such as the mechanism of growth factor receptor activation, the transport of proteins across membranes, and the physiological roles of neuronal cell adhesion molecules during nervous system development. He has been a faculty member of the Department of Cell and Developmental Biology at the University of Michigan in Ann Arbor since 1991. Dr. Hortsch has served on scientific review panels for the National Institutes of Health, the National Science Foundation, and other agencies.

 

Dr. Hisashi Umemori is a faculty member of the Molecular and Behavioral Neuroscience Institute and of the Department of Biological Chemistry at the University of Michigan Medical School. He worked with Dr. Tadashi Yamamoto at the Institute of Medical Sciences of the University of Tokyo and analyzed intracellular signaling mechanisms that are involved in myelination and in learning and memory. While working with Dr. Joshua R. Sanes at Washington University Medical School and at Harvard University, he identified synaptic organizing molecules that promote synapse formation during nervous system development. Dr. Umemori has received various awards, including a Basil O'Connor Award and a Klingenstein Fellowship Award.

 

 

Bibliographic Information

  • Book Title: The Sticky Synapse

  • Book Subtitle: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance

  • Editors: Hisashi Umemori, Michael Hortsch

  • DOI: https://doi.org/10.1007/978-0-387-92708-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2009

  • Hardcover ISBN: 978-0-387-92707-7Published: 08 July 2009

  • Softcover ISBN: 978-1-4899-8289-6Published: 11 September 2014

  • eBook ISBN: 978-0-387-92708-4Published: 07 June 2009

  • Edition Number: 1

  • Number of Pages: XII, 453

  • Topics: Neurosciences, Neurobiology, Neurology, Developmental Biology, Cell Biology

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