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Epidemiology and Biostatistics

An Introduction to Clinical Research

  • Book
  • © 2009

Overview

Authors:
  1. Bryan Kestenbaum

    1. Harborview Medical Center, University of Washington, Seattle, U.S.A.

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  • Concise, intensive introduction to clinical research design for students and clinical research professionals with no previous background in epidemiology or statistics
  • Provides students and other health professionals with the knowledge necessary to interpret clinical research articles, design clinical studies, and learn essential epidemiological concepts in an expedient manner
  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Epidemiology

    1. Front Matter

      Pages 1-1
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    2. Measures of Disease Frequency

      • Bryan Kestenbaum
      Pages 3-12

    3. General Considerations in Clinical Research Design

      • Bryan Kestenbaum
      Pages 13-24

    4. Case Reports and Case Series

      • Bryan Kestenbaum
      Pages 25-27

    5. Cross-Sectional Studies

      • Bryan Kestenbaum
      Pages 29-31

    6. Cohort Studies

      • Bryan Kestenbaum
      Pages 33-44

    7. Case-Control Studies

      • Bryan Kestenbaum
      Pages 45-57

    8. Randomized Trials

      • Bryan Kestenbaum
      Pages 59-73

    9. Misclassification

      • Bryan Kestenbaum
      Pages 75-89

    10. Introduction to Confounding

      • Bryan Kestenbaum
      Pages 91-100

    11. Methods to Control for Confounding

      • Bryan Kestenbaum
      Pages 101-111

    12. Effect Modification

      • Bryan Kestenbaum
      Pages 113-120

    13. Screening

      • Bryan Kestenbaum
      Pages 121-138

    14. Diagnostic Testing

      • Bryan Kestenbaum
      Pages 139-150

  3. Biostatistics

    1. Front Matter

      Pages 152-152
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    2. Summary Measures in Statisitics

      • Abigail B. Shoben
      Pages 153-162

    3. Introduction to Statistical Inference

      • Bryan Kestenbaum
      Pages 163-170

    4. Hypothesis Testing

      • Bryan Kestenbaum
      Pages 171-180

    5. Interpreting Hypothesis Tests

      • Abigail B. Shoben
      Pages 181-187
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Keywords

About this book

This textbook was born from a disparate collection of written materials that were created to teach Epidemiology and Biostatistics to second year medical students at the University of Washington. These materials included handouts, practice problems, guides to reading research articles, quizzes, notes from student help sessions, and student emails. The primary goal of these written materials, and now this book, is to recreate the perspective of learning Epidemiology and Biostatistics for the first time. With critical editing assistance from Epidemiology faculty, graduate students in Epidemiology and Biostatistics, and the students themselves, I have tried to preserve the innate logic and connectedness of clinical research methods and to demonstrate their application. The textbook is designed to provide students with the tools necessary to form their own informed conclusions from the clinical research literature. More than ever, a clear understanding of the fundamental aspects of Epidemiology and Biostatistics is needed to successfully navigate the increasingly complex methods utilized by modern clinical research studies. This book could not have been created without the dedicated help of the e- tors, the teaching assistants, and the students, who asked the important questions. I would especially like to thank my family who patiently allowed me so much time to write.

Reviews

From the reviews:

"In this introductory textbook, examples are carefully chosen to help readers understand important concepts in epidemiology and biostatistics, as well as their application to the field of clinical research. … the book will be useful to any healthcare practitioner interested in having a better understanding of clinical research. … This book has the important quality of providing students with an introductory overview that not only helps them understand the methods, but also guides those interested in learning more in the right direction." (Daniela Claudia Moga, Doody’s Review Service, November, 2009)

“This concise introductory textbook was ‘born from a disparate collection of written materials that were created to teach epidemiology and biostatistics to second-year medical students.’ … to provide medical students with a basic instruction to clinical epidemiology and biostatistics … . suitable for … students with no previous background in clinical epidemiology or biostatistics and for practitioners who want concise introduction to facilitate interpretation of the medical literature. … serve as the course text for a medical student introduction to clinical research methods.” (Douglas J. Lanska, Journal of the American Medical Association, Vol. 303 (18), 2010)

Authors and Affiliations

  • Harborview Medical Center, University of Washington, Seattle, U.S.A.

    Bryan Kestenbaum

About the author

Dr. Kestenbaum is an Assistant Professor, Department of Medicine, Division of Nephrology, at the University of Washington.

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