Hematopoietic Stem Cell Transplantation

1. Front Matter

   Pages i-xv

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2. Principles and Overview of Allogeneic Hematopoietic Stem Cell Transplantation

   • Sergio Giralt, Michael R. Bishop

   Pages 1-21

3. The Principles and Overview of Autologous Hematopoietic Stem Cell Transplantation

   • William Vaughan, Tara Seshadri, Mark Bridges, Armand Keating

   Pages 23-45

4. Natural Killer Cell Activity and Killer Immunoglobulin-Like Receptors in Hematopoietic Stem Cell Transplantation

   • Loredana Ruggeri, Shuhong Zhang, Sherif S. Farag

   Pages 47-69

5. Advancement and Clinical Implications of HLA Typing in Allogeneic Hematopoietic Stem Cell Transplantation

   • Lee Ann Baxter-Lowe, Carolyn Katovich Hurley

   Pages 71-94

6. Immunogenomics and Proteomics in Hematopoietic Stem Cell Transplantation: Predicting Post-Hematopoietic Stem Cell Transplant Complications

   • Eva M. Weissinger, Anne M. Dickinson

   Pages 95-129

7. Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation

   • Karl S. Peggs, Aviva C. Krauss, Crystal L. Mackall

   Pages 131-154

8. Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells

   • Daniel Fowler, Petra Hoffmann, Matthias Edinger

   Pages 155-186

9. Understanding and Enhancing the Graft-Versus-Leukemia Effect After Hematopoietic Stem Cell Transplantation

   • Jeffrey Molldrem, Stanley Riddell

   Pages 187-208

10. Reduced-Intensity and Nonmyeloablative Conditioning Regimens

    • Francine Foss, Koen van Besien

    Pages 209-232

11. Umbilical Cord Blood Transplantation

    • John E. Wagner, Claudio Brunstein, William Tse, Mary Laughlin

    Pages 233-255

12. Biology and Management of Acute Graft-Versus-Host Disease

    • Robert Korngold, Joseph H. Antin

    Pages 257-275

13. Biology and Management of Chronic Graft-Versus-Host Disease

    • Paul J. Martin, Steven Z. Pavletic

    Pages 277-298

14. Radioimmunoconjugates in Hematopoietic Stem Cell Transplantation

    • Ajay K. Gopal, Jane N. Winter

    Pages 299-315

15. Evolving Indications for Hematopoietic Stem Cell Transplantation in Multiple Myeloma and Other Plasma Cell Disorders

    • Guido Tricot, Maurizio Zangari, Roberto Sorasio, Benedetto Bruno

    Pages 317-355

16. Role of Hematopoietic Stem Cell Transplantation in the Treatment of Non-Hodgkin’s Lymphoma

    • Philip J. Bierman, Gordon L. Phillips

    Pages 357-397

17. The Role of Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma

    • Craig Moskowitz, John Sweetenham

    Pages 399-414

18. Role of Hematopoietic Stem Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndrome

    • Martin S. Tallman, Vikram Mathews, John F. DiPersio

    Pages 415-439

19. Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia

    • Daniel Weisdorf, Stephen Forman

    Pages 441-454

20. Hematopoietic Stem Cell Transplantation in Children and Adolescents with Malignant Disease

    • Mitchell S. Cairo, Thomas G. Gross

    Pages 455-496

The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

• blood
• bone marrow
• cell
• cell biology
• genomics
• hematopoietic stem cell
• hematopoietic stem cell transplantation
• immunotherapy
• leukemia
• lymphoma
• prevention
• stem cell
• stem cell transplantation
• stem cells
• transplantation

• Rockville, U.S.A.

  Michael R. Bishop

Policies and ethics